200354-41-2

Basic information

• Product Name: FMOC-D-CYS(MBZL)-OH
• Synonyms: N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-S-(4-METHYLBENZYL)-D-CYSTEINE;FMOC-D-CYSTEINE(MBZL)-OH;FMOC-D-CYS(CH3BZL)-OH;FMOC-D-CYS(MBZL)-OH;FMOC-D-CYS(PMEBZL)-OH;FMOC-S-4-METHYLBENZYL-D-CYSTEINE;Fmoc-S-4-methylbenzyl-D-cysteine≥ 98% (HPLC);(9H-Fluoren-9-yl)MethOxy]Carbonyl D-Cys(pMeBzl)-OH
• CAS NO: 200354-41-2
• Molecular Formula: C26H25NO4S
• Molecular Weight: 447.55
• Mol File: 200354-41-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 671.7 °C at 760 mmHg
• Flash Point: 360 °C
• Appearance: /
• Density: 1.278 g/cm³
• Storage Temp.: Store at RT.
• CAS DataBase Reference: FMOC-D-CYS(MBZL)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D-CYS(MBZL)-OH(200354-41-2)
• EPA Substance Registry System: FMOC-D-CYS(MBZL)-OH(200354-41-2)

Safety Data

• Hazardous Substances Data: 200354-41-2(Hazardous Substances Data)

Usage

Description

FMOC-D-CYS(MBZL)-OH, also known as 9-fluorenylmethoxycarbonyl-D-cysteine (m-benzyl), is a synthetic derivative of the naturally occurring amino acid cysteine. It is characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group and a m-benzyl (Mbzl) substituent on the sulfur atom. FMOC-D-CYS(MBZL)-OH is a white powder and is used as a building block in the synthesis of various organic compounds.

Uses

Used in Pharmaceutical Industry:
FMOC-D-CYS(MBZL)-OH is used as a reactant in the preparation of acetylenic α-amino acid-based sulfonamide hydroxamic acid TACE inhibitors. These inhibitors are important in the development of drugs targeting the tumor necrosis factor-alpha converting enzyme (TACE), which plays a crucial role in the regulation of inflammation and is implicated in various diseases, including cancer and neurodegenerative disorders.
Used in Organic Synthesis:
FMOC-D-CYS(MBZL)-OH is used as a building block in the synthesis of various organic compounds, including peptides, peptidomimetics, and other bioactive molecules. The Fmoc protecting group allows for selective deprotection and coupling reactions, making it a versatile component in organic synthesis.
Used in Research and Development:
FMOC-D-CYS(MBZL)-OH is utilized in research and development for the study of protein structure, function, and interactions. Its unique chemical properties and reactivity make it a valuable tool for investigating biological processes and developing new therapeutic agents.