200571-81-9

Basic information

• Product Name: (3-Phenyl-2-piperidin-1-yl-3,4-dihydro-quinazolin-4-yl)-acetic acid
• Synonyms: (3-Phenyl-2-piperidin-1-yl-3,4-dihydro-quinazolin-4-yl)-acetic acid
• CAS NO: 200571-81-9
• Molecular Weight: 349.433
• Mol File: 200571-81-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3-Phenyl-2-piperidin-1-yl-3,4-dihydro-quinazolin-4-yl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Phenyl-2-piperidin-1-yl-3,4-dihydro-quinazolin-4-yl)-acetic acid(200571-81-9)
• EPA Substance Registry System: (3-Phenyl-2-piperidin-1-yl-3,4-dihydro-quinazolin-4-yl)-acetic acid(200571-81-9)

Safety Data

• Hazardous Substances Data: 200571-81-9(Hazardous Substances Data)

Upstream product

• 612-41-9 2-nitrocinnamic acid 
• 659748-14-8 methyl 3-[2-(3-phenylureido)phenyl]acrylate 
• 139210-05-2 methyl 3-[2-(phenyliminomethyleneamino)phenyl]acrylate 
• 88939-75-7 methyl (2E)-3-(2-aminophenyl)propenoate 
• 39228-29-0 (E)-methyl 2-nitrocinnamate 
• 174534-47-5 4-methoxycarbonylmethyl-2-(1-piperidinyl)-3-phenyl-3,4-dihydroquinazoline 
• 110-89-4 piperidine 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 742104-68-3 KYS₀₅₀₄₀ 
• 742104-57-0 KYS₀₅₀₃₄ 

Relevant articles and documents

Solid-phase synthesis of 3,4-dihydroquinazoline

A novel, facile and efficient method for the synthesis of aryl iminophosphorane has been developed by treating a series of Ar-NH2 (1) attached to a solid support with Ph3P and diethyl azodicarboxylate at room temperature. The resulting solid-supported cinnamyl iminophosphorane (4) was treated with an aryl isocyanate to generate the corresponding solid-supported carbodiimide (5), which upon exposure to a secondary amine underwent 1,2-addition followed by an intramolecular Michael addition to afford the desired 3,4-dihydroquinazoline (7).

Synthesis and SAR studies of a novel series of T-type calcium channel blockers

For the novel, potent, and selective T-type Ca2+ channel blockers, a series of sulfonamido-containing 3,4-dihydroquinazoline derivatives were prepared and evaluated for their blocking actions on T- and N-type Ca2+ channels. Among the