20069-03-8

Basic information

• Product Name: NITRARINE
• Synonyms: NITRARINE
• CAS NO: 20069-03-8
• Molecular Formula: C20H25N3
• Molecular Weight: 307.439
• Mol File: 20069-03-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: NITRARINE(CAS DataBase Reference)
• NIST Chemistry Reference: NITRARINE(20069-03-8)
• EPA Substance Registry System: NITRARINE(20069-03-8)

Safety Data

• Hazardous Substances Data: 20069-03-8(Hazardous Substances Data)

Usage

Description

Nitrarine, an alkaloid derived from Nitraria schoberi, has been recently revised in its structure by Russian researchers. The new structure is based on ultraviolet, infrared, NMR, and mass spectrometry of the parent base, as well as X-ray crystallography of the dihydrobromide hydrate. Nitrarine exhibits unique properties that make it a valuable compound in various applications.

Uses

Used in Pharmaceutical Industry:
Nitrarine is used as an antibody-drug conjugate (ADC) for its potent anticancer properties. ADCs are a type of targeted therapy that combines the specificity of antibodies with the cytotoxic effects of chemotherapy drugs. Nitrarine's unique structure allows it to be effectively linked to antibodies, enabling the targeted delivery of chemotherapy drugs to cancer cells and minimizing damage to healthy cells.
Used in Synthesis of Anti-EGFR Antibody Conjugates:
Nitrarine is also utilized in the synthesis of anti-epidermal growth factor receptor (EGFR) antibody conjugates. EGFR is a protein commonly overexpressed in various types of cancer, making it an attractive target for antibody-based therapies. By conjugating Nitrarine to anti-EGFR antibodies, researchers can develop more effective and targeted treatments for EGFR-overexpressing cancers.

References

Ibragimov et al., Khim. Prir. Soedin., 11,273 (1975)