20096-53-1 Usage
Description
2,6-ANS, also known as 2-(4-aminophenyl)-6-methoxybenzothiazole, is a fluorescent dye widely utilized in biochemical and biophysical research. It is recognized for its capacity to bind to the hydrophobic regions of proteins and membranes, which renders it an advantageous tool for investigating protein-protein interactions, protein folding, and membrane dynamics. Furthermore, 2,6-ANS has been employed in the characterization of amyloid fibrils and aggregates, exhibiting potential for diagnosing amyloid-related diseases. Its fluorescent characteristics and specificity for hydrophobic binding sites make it a valuable asset in research areas concerning protein and membrane biology.
Uses in Biochemical and Biophysical Research:
2,6-ANS is used as a fluorescent probe for studying protein-protein interactions and protein folding due to its ability to bind to hydrophobic pockets in proteins and membranes.
Used in the Characterization of Amyloid Fibril and Aggregates:
2,6-ANS is used as a diagnostic tool for amyloid-related diseases, as it can bind to and characterize amyloid fibrils and aggregates, aiding in the detection and study of these conditions.
Used in Membrane Dynamics Studies:
2,6-ANS is used as a fluorescent marker for analyzing membrane dynamics, given its propensity to interact with the hydrophobic regions of biological membranes.
Check Digit Verification of cas no
The CAS Registry Mumber 20096-53-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,0,9 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 20096-53:
(7*2)+(6*0)+(5*0)+(4*9)+(3*6)+(2*5)+(1*3)=81
81 % 10 = 1
So 20096-53-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H13NO3S/c18-21(19,20)16-9-7-12-10-15(8-6-13(12)11-16)17-14-4-2-1-3-5-14/h1-11,17H,(H,18,19,20)
20096-53-1Relevant articles and documents
Spectroscopic determination of pressure-induced shifts in inclusion complexation equilibria
Evans, Christine E.
, p. 2136 - 2142 (2007/10/03)
The effect of modest hydrostatic pressure (c ranging from clearly pressure dependent (-14%) to pressure independent over 338 bar. Additional solvation perturbations are observed in the pressure dependence of the quantum efficiency for both complexes (-7.3% and -9.4%). Thus, pressure-induced perturbation in the fluorescence properties of the complex need not be accompanied by simultaneous changes in the complexation equilibrium. Finally, these pressure-induced changes in complexation selectivity are important for all measurements conducted under variable pressure conditions, including liquid chromatography and process monitoring.
