201152-47-8

Basic information

• Product Name: BOC-PHG-OSU
• Synonyms: BOC-L-PHENYLGLYCINE HYDROXY-SUCCINIMIDE ESTER;BOC-L-PHENYLGLYCINE N-HYDROXYSUCCINIMIDE ESTER;BOC-PHG-OSU;BOC-PHENYLGLYCINE-OSU;BOC-L-PHENYLGLYCINE HYDROXY-SUCCINIMIDESTER;Boc-L-phenylglycineN-hydroxysuccinimide ester99%;Boc-L-Phg-OSu
• CAS NO: 201152-47-8
• Molecular Formula: C₁₇H₂₀N₂O₆
• Molecular Weight: 348.35
• Mol File: 201152-47-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: BOC-PHG-OSU(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-PHG-OSU(201152-47-8)
• EPA Substance Registry System: BOC-PHG-OSU(201152-47-8)

Safety Data

• Hazardous Substances Data: 201152-47-8(Hazardous Substances Data)

Usage

General Description

BOC-PHG-OSU is a chemical compound commonly used in the synthesis of peptides. It is a carbodiimide coupling reagent that is known for its ability to efficiently and selectively activate carboxylic acids for amide bond formation. BOC-PHG-OSU has been widely utilized in the pharmaceutical and biotechnology industries for the production of peptides with specific sequences and structures. Its high efficiency and mild reaction conditions make it a popular choice for peptide synthesis, allowing for the rapid and reliable formation of peptide bonds.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 2900-27-8 (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid 
• 2935-35-5 (S)-2-phenylglycine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 155322-81-9 (S)-2-amino-N-benzyl-2-phenylacetamide 
• 135832-70-1 ((1S,2S,4R)-1-Benzyl-4-{[(S)-(3-dimethylamino-propylcarbamoyl)-phenyl-methyl]-carbamoyl}-2-hydroxy-5-phenyl-pentyl)-carbamic acid tert-butyl ester 
• 135832-68-7 {(1S,2S,4R)-1-Benzyl-4-[((S)-benzylcarbamoyl-phenyl-methyl)-carbamoyl]-2-hydroxy-5-phenyl-pentyl}-carbamic acid tert-butyl ester 
• 135911-86-3 [(1S,2S,4R)-4-({(S)-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-phenyl-methyl}-carbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester 
• 1133822-80-6 spiro[(4-ethyl-7,8-dihydropyrano[3,2-g]chromen-2-one)-8,1'-cyclohexane] N-(N-tert-butyloxycarbonyl-L-2-phenylglycyl)hydrazone 
• 117422-78-3 (S)-tert-butyl (2-(benzylamino)-2-oxo-1-phenylethyl)carbamate 

Relevant articles and documents

Synthesis of amino acid derivatives of hydrazones and oximes of spirodihydropyranochromen-2-ones

Sulfur-and nitrogen-containing derivatives of spirodihydropyranochromen-2- ones at the exocyclic oxygen atom have been synthesized. Modification of the oximes and hydrazones of the spiro-substituted pyranocoumarins with N-substituted amino acids were carried out using activated ester and symmetrical anhydride methods.

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679

A series of tetrapeptide analogues of 1 (L-682,679), in which the carboxy terminus has been shortened and modified, was prepared and their inhibitory activity measured against the HIV protease in a peptide cleavage assay. Selected examples were tested as inhibitors of virus spread in cell culture. Compound 12 was a 10-fold more potent enzyme inhibitor than 1 in vitro and 30-fold more potent in inhibiting the viral spread in cells.