2015-19-2

Basic information

• Product Name: 5-Amino-2-chlorobenzenesulfonamide
• Synonyms: 4-CHLOROANILINE-3-SULFONAMIDE;4-CHLOROANILINE-3-SULPHONAMIDE;5-AMINO-2-CHLOROBENZENESULFONAMIDE;5-amino-2-chlorobenzenesulphonamide;4-Chloroaniline-3-sulfonamid;5-azanyl-2-chloro-benzenesulfonamide;2-Chloro-5-aMinobenzenesulfonaMide;3-AMinosulfonyl-4-chloroaniline
• CAS NO: 2015-19-2
• Molecular Formula: C₆H₇ClN₂O₂S
• Molecular Weight: 206.65
• EINECS: 217-943-0
• Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Amines;Sulfur & Selenium Compounds
• Mol File: 2015-19-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 169-171°C
• Boiling Point: 454.5°Cat760mmHg
• Flash Point: 228.7°C
• Appearance: Light Browm Solid
• Density: 1.558
• Vapor Pressure: 1.89E-08mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO, Ethyl Acetate, Methanol
• PKA: 9.92±0.60(Predicted)
• CAS DataBase Reference: 5-Amino-2-chlorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2-chlorobenzenesulfonamide(2015-19-2)
• EPA Substance Registry System: 5-Amino-2-chlorobenzenesulfonamide(2015-19-2)

Safety Data

• Hazardous Substances Data: 2015-19-2(Hazardous Substances Data)

Usage

Chemical Properties

Light Browm Solid

InChI:InChI=1/C6H7ClN2O2S/c7-5-2-1-4(8)3-6(5)12(9,10)11/h1-3H,8H2,(H2,9,10,11)

Upstream product

• 96-72-0 2-chloro-5-nitrobenzenesulfonamide 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 4533-95-3 5-nitro-2-chlorobenzenesulfonyl chloride 
• 100-00-5 4-chlorobenzonitrile 
• 946-30-5 2-chloro-5-nitrobenzenesulphonic acid sodium salt 
• 96-73-1 2-chloro-5-nitro-benzenesulfonic acid 

Downstream Products

• 145389-81-7 N-(4-chloro-3-sulfamoylphenyl)-2-nitroethyleneamine 
• 87739-63-7 2-Chloro-5-(4,6-diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl)-benzenesulfonamide; hydrochloride 
• 2890-73-5 N-(4-chloro-3-sulfamoylphenyl)acetamide 

Relevant articles and documents

Controllable Soil Degradation Rate of 5-Substituted Sulfonylurea Herbicides as Novel AHAS Inhibitors

Chlorsulfuron has been applied in wheat fields as a recognized herbicide worldwide, yet it was officially banned in China since 2014 for its soil persistence problem. On the basis of our previous research that 5-dimethylamino distinctively accelerated degradation rate in soils, a modified amino moiety (Ia-c) and monosubstituted amino group (Id-e) were introduced onto the fifth position of the benzene ring in sulfonylurea structures, as well as heterocyclic amino substituents (If-g) to seek a suitable soil degradation rate during such an in situ crop rotation system. Referring to the biological data and ScAHAS inhibition and ScAHAS docking results, they turned out to be AHAS inhibitors with high potent herbicidal activities. The various influence on soil degradation rate along with crop safety indicated that different substituents on the fifth position have exerted an apparent impact. Their united study of structure-activity-safety-degradation relationship has great potential to provide valuable information for further development of eco-friendly agrochemicals.

TGF-betaR1 inhibitor and application thereof

The invention belongs to the field of medical chemistry, and particularly relates to a compound serving as a TGF-betaR1 inhibitor and application of the compound. Specifically, the invention providesa compound shown as a formula I or an isomer, a pharmaceutically acceptable salt, a solvate, a crystal or a prodrug thereof, a preparation method of the compounds, a pharmaceutical composition containing the compounds and application of the compounds or the composition to treatment and/or prevention of TGF-betaR1 related diseases, such as cancers, tissue hyperplasia diseases, fibrosis and inflammatory diseases. The compound provided by the invention shows significant inhibitory activity on TGF-betaR1 kinase, and is very expected to become a therapeutic agent for TGF-betaR1 related diseases.

Research on controllable degradation of sulfonylurea herbicides

In order to seek ecologically safer and environmentally benign sulfonylurea herbicides (SU), insight into the structure/bioassay/soil degradation tri-factor relationship was first established. With the introduction of various groups (alkyl, nitro, halogen, cyano etc.) at the 5th position of its benzene ring, structural derivatives of chlorsulfuron were designed, synthesized, and evaluated for their herbicidal activity. The structures of the title compounds were confirmed by infrared spectroscopy, ultraviolet spectroscopy, 1H and 13C NMR, mass spectrometry, elemental analysis and X-ray diffraction. Bioassay results confirmed that most derivatives retained their superior herbicidal activities in comparison with chlorsulfuron. After investigating the soil degradation behavior of each molecule under set conditions, it was found that structures with electron-withdrawing substituents at the 5th position of the benzene ring retained their long degradation half-lives, yet the introduction of electron-donating substituents accelerated the degradation rate. These results will provide a valuable clue to further explore the potential controllable degradation of SU and other herbicides, and to discover novel herbicides that are favorable for environmentally and ecologically sustainable development.