2040-44-0

Basic information

• Product Name: 2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER
• Synonyms: 2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER;rac Ethyl 2-(Benzyloxy)propionate;2-Benzyloxypropionic Acid Ethyl Ester;Ethyl 2-(Benzyloxy)propanoate;Levofloxacin rac Ethyl 2-(Benzyloxy)propionate
• CAS NO: 2040-44-0
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.25
• Product Categories: Aromatics;Chiral Reagents
• Mol File: 2040-44-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 294.9 °C at 760 mmHg
• Flash Point: 102.8 °C
• Appearance: /
• Density: 1.049 g/cm³
• Vapor Pressure: 0.00157mmHg at 25°C
• Refractive Index: 1.494
• CAS DataBase Reference: 2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER(2040-44-0)
• EPA Substance Registry System: 2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER(2040-44-0)

Safety Data

• Hazardous Substances Data: 2040-44-0(Hazardous Substances Data)

Usage

Description

2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER is an organic compound that is characterized by its ester functional group and phenylmethoxy substituent. It is a colorless liquid with a distinct aromatic odor and is soluble in organic solvents. 2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER is known for its role in the synthesis of various pharmaceuticals and has potential applications in the chemical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
2-(PHENYLMETHOXY)-PROPANOIC ACID ETHYL ESTER is used as an intermediate in the synthesis of optically active 2-hydroxypropoxyaniline derivatives. These derivatives are crucial for the production of Levofloxacin, a widely used antibiotic, through enzymic or microbial stereoselective hydrolysis of racemic lactic acid ester. The compound's role in this process highlights its importance in the development of effective treatments for bacterial infections.

InChI:InChI=1/C12H16O3/c1-3-14-12(13)10(2)15-9-11-7-5-4-6-8-11/h4-8,10H,3,9H2,1-2H3

Upstream product

• 687-47-8 (S)-Ethyl lactate 
• 100-39-0 benzyl bromide 
• 97-64-3 ethyl L-lactate 
• 54783-72-1 ethyl (S)-2-(benzyloxy)propionate 
• 100-51-6 benzyl alcohol 
• 10488-87-6 ethyl 2-benzoylpropionate 
• 100-44-7 benzyl chloride 
• 535-11-5 Ethyl 2-bromopropionate 
• 97-64-3 ethyl 2-hydroxypropionate 

Downstream Products

• 33106-26-2 2-benzyloxypropanol 
• 33106-64-8 (S)-2-(benzyloxy)propan-1-ol 
• 100836-85-9 (R)-2-benzyloxypropionic acid 
• 87037-69-2 (R)-2-(benzyloxy)propan-1-ol 
• 87841-71-2 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-benzyloxy-propyl ester 
• 87841-70-1 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-2-benzyloxy-propyl ester 
• 100423-74-3 ethyl (2R)-2-(benzyloxy)propanoate 
• 110720-14-4 O-(Lac)-benzyldidemnin B 
• 110720-44-0 (Bzl-Lac-Pro)2O 
• 111752-63-7 ethyl (E)-4-benzyloxypent-2-enoate 
• 111752-64-8 ethyl (Z)-4-benzyloxypent-2-enoate 
• 87938-26-9 (±)-(2S,3S)-2-(benzyloxy)hex-5-en-3-ol 
• 53346-05-7 2-(benzyloxy)propanal 

Relevant articles and documents

Lewis-base-catalysed selective reductions of ynones with a mild hydride donor

Ynones are efficiently reduced with a mild hydride donor in the presence of a catalytic amount of nucleophilic phosphines. The reactions are selective 1,2-reductions that give propargyl alcohols in yields of up to 96%. It is proposed that success in these reactions depends on the activation of ynones by a Lewis base catalyst. A protic additive plays a key role in suppressing the undesired reaction pathways and accelerating the 1,2-reductions.

PROCESS FOR PREPARATION OF OPTICALLY ACTIVE PROPOXYANILINE DERIVATIVES

Treatment of a lactic acid ester derivative with an enzyme or the like, which has asymmetric ester-hydrolyzing ability, can specifically hydrolyze the ester moiety of an isomer existing as the pair to the racemic derivative. Use of the compound obtained by this hydrolysis makes it possible to produce an optically active propoxyaniline derivative by a shorter process than the conventional art.

Cesium promoted O-alkylation of alcohols for the efficient ether synthesis

Efficient Williamson type O-alkylation of alcohols was developed using cesium bases in the presence of tetrabutylammonium iodide (TBAI) and molecular sieves. Various substrates including unreactive primary and secondary alcohols were converted smoothly to