2043-38-1 Usage
Chemical Properties
Off-White Solid
Originator
Saltucin,Boehringer Mannheim,W. Germany,1961
Manufacturing Process
Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which
when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl
ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a
saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The
reaction mixture is concentrated under reduced pressure, an oily product
precipitates on the addition of water, the latter is decanted and ethanol added
to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-
benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from
dimethylformamide and water, melts at 241°-245°C.
Therapeutic Function
Diuretic, Antihypertensive
Check Digit Verification of cas no
The CAS Registry Mumber 2043-38-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,4 and 3 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2043-38:
(6*2)+(5*0)+(4*4)+(3*3)+(2*3)+(1*8)=51
51 % 10 = 1
So 2043-38-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H16ClN3O4S2/c1-6(2)3-11-14-8-4-7(12)9(20(13,16)17)5-10(8)21(18,19)15-11/h4-6,11,14-15H,3H2,1-2H3,(H2,13,16,17)
2043-38-1Relevant articles and documents
Thiadiazine compound and asymmetric synthetic method thereof
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Paragraph 0051-0052, (2017/01/23)
The invention relates to a thiadiazine compound and an asymmetric synthetic method thereof. According to the method, transition metal and chiral oxazoline ligand complexes are used as catalysts, orthanilamide and aldehyde are used as reactants, and condensation and asymmetric addition are performed, so as to obtain the chiral thiadiazine compound. The method has important application prospect in synthesizing chiral thiadiazine diuretic drugs.
