205533-31-9

Basic information

• Product Name: 4,5-Difluoro-2-hydroxy-benzoic acid
• Synonyms: 4,5-Difluoro-2-hydroxy-benzoic acid
• CAS NO: 205533-31-9
• Molecular Formula: C₇H₄F₂O₃
• Molecular Weight: 174.1016664
• Mol File: 205533-31-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4,5-Difluoro-2-hydroxy-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Difluoro-2-hydroxy-benzoic acid(205533-31-9)
• EPA Substance Registry System: 4,5-Difluoro-2-hydroxy-benzoic acid(205533-31-9)

Safety Data

• Hazardous Substances Data: 205533-31-9(Hazardous Substances Data)

Usage

Description

4,5-Difluoro-2-hydroxy-benzoic acid is a fluorinated derivative of salicylic acid, characterized by the presence of two fluorine atoms at the fourth and fifth positions on the benzene ring. This white crystalline solid is a valuable intermediate in the synthesis of pharmaceuticals and agrochemicals, with its hydroxy group enabling the production of various organic compounds. Its anti-inflammatory and anti-bacterial properties make it a promising candidate for the development of new drugs, and its versatile structure and properties position it as a building block in organic chemistry with applications across multiple industries.

Uses

Used in Pharmaceutical Industry:
4,5-Difluoro-2-hydroxy-benzoic acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with anti-inflammatory and anti-bacterial properties.
Used in Agrochemical Industry:
4,5-Difluoro-2-hydroxy-benzoic acid is utilized as a building block in the creation of agrochemicals, where its unique structure and properties can enhance the effectiveness of products designed for agricultural applications.
Used in Organic Chemistry:
4,5-Difluoro-2-hydroxy-benzoic acid serves as a versatile intermediate in organic chemistry, facilitating the synthesis of a wide range of organic compounds for various applications in different industries.

Upstream product

• 446-17-3 2,4,5-trifluorobenzoic acid 
• 425702-18-7 2-methoxy-4,5-difluorobenzoic acid 
• 88419-56-1 2,4,5-trifluorobenzoyl chloride 
• 80-73-9 1,3-dimethyl-2-imidazolidinone 
• 749230-48-6 2-chloro-3,4-difluoro-1-(methoxymethoxy)benzene 
• 749230-22-6 1,2-difluoro-4-(methoxymethoxy)benzene 
• 749230-49-7 3-chloro-4,5-difluoro-2-hydroxybenzoic acid 

Downstream Products

• 1015434-11-3 2-acetyloxy-4,5-difluorobenzoic acid 
• 1338075-39-0 methyl 2-(5-(tert-butoxycarbonyl(2,4-dimethoxybenzyl)amino)pentyloxy)-4,5-difluorobenzoate 
• 1338075-40-3 tert-butyl 5-((4,5-difluoro-2-hydroxymethyl)phenoxy)-pentyl-(2,4-dimethoxybenzyl)-carbamate 
• 1214375-32-2 methyl 4,5-difluoro-2-hydroxybenzoate 

Relevant articles and documents

APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS AND USES THEREOF

Described herein are ASK1 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of blood disease, autoimmune disorders, pulmonary disorders, hypertension, inflammatory diseases, fibrotic diseases, diabetes, diabetic nephropathy, renal diseases, respiratory diseases, cardiovascular diseases, acute lung injuries, acute or chronic liver diseases, and neurodegenerative diseases.

A convenient and efficient approach to polyfluorosalicylic acids and their tuberculostatic activity

We have developed the practical method for polyfluorosalicylic acids synthesis via nucleophilic ortho-mono-substitution of fluorine atom with magnesium methoxide. We have managed to increase the yield of targeted polyfluorosalicylic acids from good to quantitative. We have studied the tuberculostatic activity of polyfluorosalicylic acids. It has been found that minimum inhibitory concentration (MIC) of compounds is from 0.7 to 6.5 μg/mL depending on the structure.

The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates

2,4-Difluorophenol, 2,5-difluorophenol, 2,3-difluorophenol, 3,5-difluorophenol, 3,4-difluorophenol, 2,4,5-trifluorophenol and 2,3,4-trifluorophenol were converted into all 18 possible di- or trifluorinated hydroxybenzoic acids (1a-c, 4a-c, 9a-c, 12a,b, 14a-c, 17a,b, 18a,b), all of them new compounds. The phenolic hydrogen atom was replaced by a methoxymethyl or, less frequently, by a triisopropylsilyl group, which exerted an ortho activating or ortho shielding effect, respectively. Sites flanked by two electronegative substituents (fluorine, alkoxy) were deprotonated with particular ease. They had to be silenced by the reversible attachment of a metalation-blocking trimethylsilyl group or of a metalation-deflecting chlorine atom if the metal was to be introduced elsewhere. In all cases but one, the stage was thus set for an intramolecular competition between metalation at an oxygen-adjacent or a fluorine-adjacent site. It proved indeed possible to secure the desired regioflexibility in either way by relying on an appropriate substrate-reagent matching. This demonstrates once more the potential of the organometallic approach to diversity-oriented synthesis.