2059-29-2

Basic information

• Product Name: 6-fluorobenzo[cd]indol-2(1H)-one
• Synonyms: 6-fluorobenzo[cd]indol-2(1H)-one
• CAS NO: 2059-29-2
• Molecular Weight: 187.173
• Mol File: 2059-29-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-fluorobenzo[cd]indol-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluorobenzo[cd]indol-2(1H)-one(2059-29-2)
• EPA Substance Registry System: 6-fluorobenzo[cd]indol-2(1H)-one(2059-29-2)

Safety Data

• Hazardous Substances Data: 2059-29-2(Hazardous Substances Data)

Upstream product

• 438-32-4 4-Fluoro-1-aminonaphthalene 

Relevant articles and documents

Cobalt-Catalyzed Direct Carbonylative Synthesis of Free (NH)-Benzo[ cd]indol-2(1 H)-ones from Naphthylamides

A cobalt-catalyzed C-H carbonylation of naphthylamides for the synthesis of benzo[cd]indol-2(1H)-one scaffolds has been developed. The reaction employs a traceless directing group and uses benzene-1,3,5-triyl triormate as the CO source, affording various free (NH)-benzo[cd]indol-2(1H)-ones in moderate to high yields (up to 88%). Using this protocol, the total synthesis of BET bromodomain inhibitors A and B was accomplished as well.