206061-69-0

Basic information

• Product Name: 2-picolylthiophosphoro-bis-triazolide
• Synonyms: 2-picolylthiophosphoro-bis-triazolide
• CAS NO: 206061-69-0
• Molecular Weight: 291.276
• Mol File: 206061-69-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-picolylthiophosphoro-bis-triazolide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-picolylthiophosphoro-bis-triazolide(206061-69-0)
• EPA Substance Registry System: 2-picolylthiophosphoro-bis-triazolide(206061-69-0)

Safety Data

• Hazardous Substances Data: 206061-69-0(Hazardous Substances Data)

Upstream product

• 4377-33-7 2-chloromethylpyridine 

Downstream Products

• 206061-72-5 5'-O-DMT-thymidine-3'-(2-picoline)thiophosphonate 
• 189153-35-3 5'-O-DMT-thymidine-3'-(2-picoline)thiophosphate 
• 189153-41-1 C₄₉H₅₂N₅O₁₄PS 

Relevant articles and documents

A new strategy for the synthesis of phosphorothioates of 2′-deoxyriboligonucleotides

2-Picoline thiol, a new reagent, has been indigenously prepared and a new strategy has been followed for the sulphurization of phosphate bond in nucleotide monomer. The 2-picolylthiophosphorobis-(triazolide) has been prepared using phosphite triester approach and treated with protected nucleosides to get phosphorothioate synthons. The two dimers, d(GpT) and d(TpT) have been synthesised in very good yields using these synthons. The removal of 2-methylpyridyl group at the end of synthesis is achieved with 1,1,3,3-tetramethylguanidinium-4-nitrobenzaldoxime in dioxane-water.