20771-60-2

Basic information

• Product Name: Benzene, 1-isocyano-2-methoxy- (9CI)
• Synonyms: Benzene, 1-isocyano-2-methoxy- (9CI);o-Methoxyphenyl isocyanide;Benzene,1-isocyano-2-methoxy-
• CAS NO: 20771-60-2
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.14728
• Product Categories: ISONITRITE
• Mol File: 20771-60-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzene, 1-isocyano-2-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-isocyano-2-methoxy- (9CI)(20771-60-2)
• EPA Substance Registry System: Benzene, 1-isocyano-2-methoxy- (9CI)(20771-60-2)

Safety Data

• Hazardous Substances Data: 20771-60-2(Hazardous Substances Data)

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 23896-88-0 formic acid o-anisidide 

Downstream Products

• 23896-88-0 formic acid o-anisidide 
• 101671-39-0 1,3-Dihydro-7-methoxy-3-(2-methoxyphenylimino)-2H-indol-2-on 
• 101671-38-9 2-(α-Ethoxybenzyliden)-7-methoxy-3-(methoxyphenylamino)-2H-indol 
• 101671-37-8 2-(α-Ethoxybenzyliden)-7-methoxy-3-(2-methoxyphenylamino)-2H-indol 
• 101671-26-5 2-Benzoyl-7-methoxy-3-(2-methoxyphenylamino)-1H-indol 
• 99584-32-4 1-(2-methoxyphenyl)-1H-1,2,3,4-tetrazole 
• 181209-82-5 CH₃OC₆H₄NC(Ga(CH(Si(CH₃)3)2)2)C(Ga(CH(Si(CH₃)3)2)2)NC₆H₄OCH₃ 
• 1148034-51-8 [IPd(μ-dppm)2(μ-CN-C6H4-OMe)PtI] 
• 1126895-97-3 [ClPd(μ-dppm)2(μ-CN-C6H4-OMe)PtCl] 

Relevant articles and documents

Palladium-catalyzed secondary benzylic imidoylative reactions

Reported herein is a palladium-catalyzed secondary benzylic imidoylative Negishi reaction leveraging the sterically bulky aromatic isocyanides as the imine source. This method allows the facile access of alkyl-, (hetero)aryl-, and alkynylzinc reagents to afford various α-substituted phenylacetone products under mild acidic hydrolysis, which are ubiquitous motifs in many pharmaceuticals and biologically active compounds. The diastereoselective reduction of imine can be accomplished to provide the expedient conversion of secondary benzylic halide into α-substituted phenethylamine derivatives with high atom economy.

Visible-Light-Induced Radical Cascade Cyclization: Synthesis of the ABCD Ring Cores of Camptothecins

A new strategy for constructing indolizino[1,2-b]quinolin-9(11H)-ones (ring cores of camptothecins) from readily available isocyanoarenes and N-(alkyl-2-yn-1-yl)pyridin-2(1H)-ones has been developed through a visible-light-induced radical cascade cyclization process. The reaction proceeds under mild conditions with fair to excellent yields. The easy introduction of substituents for both reactants and the broad functional group tolerance of the reaction make it a straightforward route to the cores of the marketed camptothecins and their derivatives.

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors

A series of benzenesulfonamides bearing selenourea moieties was obtained considering the ureido-sulfonamide SLC-0111, in Phase I clinical trials as antitumor agent, as a lead molecule. All compounds showed interesting inhibition potencies against the physiologically relevant human (h) carbonic anhydrase (hCAs, EC 4.2.1.1) isoforms I, II, IV, and IX. The most flexible analogues in the series 14-19 showed low nanomolar inhibition constants against hCA I, II, and IX. We assessed selected compounds on the in vitro antioxidant properties and binding modes and evaluated ex vivo human prostate (PC3), breast (MDA-MB-231), and colon-rectal (HT-29) cancer cell lines both in normoxic and hypoxic conditions.