207743-19-9

Basic information

• Product Name: methyl 2-methoxy-5-{[4-methoxy-3-(methoxycarbonyl)phenyl]methyl}benzoate
• Synonyms: methyl 2-methoxy-5-{[4-methoxy-3-(methoxycarbonyl)phenyl]methyl}benzoate
• CAS NO: 207743-19-9
• Molecular Weight: 344.364
• Mol File: 207743-19-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 2-methoxy-5-{[4-methoxy-3-(methoxycarbonyl)phenyl]methyl}benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-methoxy-5-{[4-methoxy-3-(methoxycarbonyl)phenyl]methyl}benzoate(207743-19-9)
• EPA Substance Registry System: methyl 2-methoxy-5-{[4-methoxy-3-(methoxycarbonyl)phenyl]methyl}benzoate(207743-19-9)

Safety Data

• Hazardous Substances Data: 207743-19-9(Hazardous Substances Data)

Upstream product

• 122-25-8 5,5'-methylenedisalicylic acid 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 207743-20-2 4,4'-Dimethoxy-3,3'-bis(methoxycarbonyl)benzophenone 
• 207743-24-6 3,3'-Diiodo-4,4',-dimethoxy-5,5'-bis(methoxycarbonyl)benzophenone 
• 207743-23-5 3,3'-diamino-5,5'-bis(methoxycarbonyl)-4,4'-dimethoxybenzophenone 
• 207743-21-3 4',4-Dimethoxy-3',3-bis(methoxycarbonyl)-1,1-diphenyl-1-heptene 
• 207743-22-4 4,4'-dimethoxy-3,3'-dimethoxycarbonyl-5,5'-dinitrobenzophenone 
• 122-25-8 5,5'-methylenedisalicylic acid 
• 244262-30-4 1,1-bis[3-(4'-methoxy-3'-methoxycarbonylbenzamido)-4-methoxy-5-methoxycarbonylphenyl]methane 
• 244262-25-7 1,1-bis(3-amino-4-methoxy-5-methoxycarbonylphenyl)methane 
• 244262-21-3 1,1-bis(4-methoxy-3-methoxycarbonyl-5-nitrophenyl)methane 

Relevant articles and documents

Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity

DNA methylation is an epigenetic modification that is performed by DNA methyltransferases (DNMTs) and that leads to the transfer of a methyl group from S-adenosylmethionine (SAM) to the C5 position of cytosine. This transformation results in hypermethylation and silencing of genes such as tumor suppressor genes. Aberrant DNA methylation has been associated with the development of many diseases, including cancer. Inhibition of DNMTs promotes the demethylation and reactivation of epigenetically silenced genes. NSC 106084 and 14778 have been reported to inhibit DNMTs in the micromolar range. We report herein the synthesis of NSC 106084 and 14778 and the evaluation of their DNMT inhibitory activity. Our results indicate that while commercial NSC 14778 is moderately active against DNMT1, 3A/3L and 3B/3L, resynthesized NSC 14778 is inactive under our assay conditions. Resynthesized 106084 was also found to be inactive.

New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors

Twenty-two new alkenyldiarylmethanes (ADAMs) were synthesized and evaluated for inhibition of HIV-1 replication. The most potent compound proved to be methyl 3',3'-dichloro-4',4'dimethoxy-5',5'-bis(methoxycarbonyl)- 6,6-diphenyl-5-hexenoate (ADAM II), whi