21133-98-2

Basic information

• Product Name: ethyl 3-(p-chlorophenyl)-3-hydroxybutyrate
• Synonyms: ethyl 3-(p-chlorophenyl)-3-hydroxybutyrate;4-Chloro-β-hydroxy-β-methylbenzenepropanoic acid ethyl ester;Einecs 244-235-9
• CAS NO: 21133-98-2
• Molecular Formula: C₁₂H₁₅ClO₃
• Molecular Weight: 242.6987
• EINECS: 244-235-9
• Mol File: 21133-98-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 359°Cat760mmHg
• Flash Point: 170.9°C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 8.89E-06mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: ethyl 3-(p-chlorophenyl)-3-hydroxybutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(p-chlorophenyl)-3-hydroxybutyrate(21133-98-2)
• EPA Substance Registry System: ethyl 3-(p-chlorophenyl)-3-hydroxybutyrate(21133-98-2)

Safety Data

• Hazardous Substances Data: 21133-98-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15ClO3/c1-3-16-11(14)8-12(2,15)9-4-6-10(13)7-5-9/h4-7,15H,3,8H2,1-2H3

Upstream product

• 18295-66-4 1-ethoxy-1-(trimethylsiloxy)ethene 
• 99-91-2 para-chloroacetophenone 
• 105-36-2 ethyl bromoacetate 
• 623-48-3 ethyl iodoacetae 

Downstream Products

• 21758-07-6 3-(4-chloro-phenyl)-crotonic acid 
• 1243130-08-6 ethyl 3-methyl-3-p-chlorophenylpropionate 
• 54795-05-0 6-Chlor-3-methylindanon 
• 81187-90-8 (Z)-4-Bromo-3-(4-chloro-phenyl)-but-2-enoic acid 
• 81244-20-4 (E)-4-Bromo-3-(4-chloro-phenyl)-but-2-enoic acid 
• 81187-91-9 (Z)-4-amino-3-(4-chlorophenyl)but-2-enoic acid 
• 81187-92-0 (E)-4-amino-3-(4-chlorophenyl)but-2-enoic acid 
• 26717-53-3 4-(4-chlorophenyl)furan-2(5H)-one 
• 81187-93-1 4-(4-chlorophenyl)-1,5-dihydro-2H-pyrrol-2-one 
• 1134-47-0 4-amino-3-(4-chlorophenyl)butanoic acid 
• 22518-27-0 4-(4-chlorophenyl)pyrrolidin-2-one 
• 537676-64-5 ethyl 4-azido-3-(4-chlorophenyl)-2-butenoate 
• 114566-93-7 ethyl 4-bromo-3-(4-chlorophenyl)-2-butenoate 
• 147224-53-1 (R)-ethyl 4-azido-3-(4-chlorophenyl)-1-butanoate 

Relevant articles and documents

Access to β-Hydroxyl Esters via Copper-Catalyzed Reformatsky Reaction of Ketones and Aldehydes

An efficient and simple Cu-catalyzed Reformatsky reaction of ketones and aldehydes has been accomplished with ethyl iodoacetate. Excellent yields of β-hydroxyl esters were achieved with a range of ketones and aldehydes, which varied from aromatic to aliphatic, unsaturated to saturated ketones and aldehydes. This practical and convenient transformation was conducted with inexpensive, readily available, and commercial starting materials under mild reaction conditions.

Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds

An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.

Cp2ZrCl2-induced Reformatsky and Barbier reactions on isatins: An efficient synthesis of 3-substituted-3-hydroxyindolin-2-ones

A mild and rapid one-pot process for Reformatsky and Barbier reactions using a catalytic quantity of zirconocene dichloride (Cp2ZrCl 2) as a promoter and zinc as a terminal reductant at room temperature in dimethyl formamide was developed. The protocol has wide substrate suitability and afforded the desired 3-substituted-3-hydroxyindolin-2-ones from istains in good yields and short reaction time.