21147-18-2

Basic information

• Product Name: Methanone, (2-hydroxyphenyl)(2-methoxyphenyl)-
• Synonyms: 2-hydroxy-2'-methoxy-benzophenone;2-Hydroxy-2'-methoxy-benzophenon;2-hydroxy-2'-methyloxybenzophenone
• CAS NO: 21147-18-2
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Mol File: 21147-18-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 77°C
• CAS DataBase Reference: Methanone, (2-hydroxyphenyl)(2-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-hydroxyphenyl)(2-methoxyphenyl)-(21147-18-2)
• EPA Substance Registry System: Methanone, (2-hydroxyphenyl)(2-methoxyphenyl)-(21147-18-2)

Safety Data

• Hazardous Substances Data: 21147-18-2(Hazardous Substances Data)

Usage

Preparation

Preparation from 2-iodophenyl 2-methoxybenzoate by treatment with n-butyllithium in a mixture of ethyl ether, hexane and tetrahydrofuran at ?70° for 2 h, followed by treatment with saturated aqueous ammonium chloride (93%).

Upstream product

• 129103-71-5 2-iodophenyl 2-methoxybenzoate 
• 835-11-0 2,2'-dihydroxybenzophenone 
• 77-78-1 dimethyl sulfate 
• 678967-04-9 (2-(benzyloxy)-phenyl)(2-methoxyphenyl)methanone 
• 74-88-4 methyl iodide 
• 13102-33-5 2,2'-dimethoxybenzophenone 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 579-75-9 2-Methoxybenzoic acid 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 90-47-1 xanth-9-one 
• 124-41-4 sodium methylate 
• 1532528-32-7 C₁₇H₂₀O₃Si 
• 529-28-2 4-iodoanisol 

Downstream Products

• 5293-79-8 3-(o-methoxyphenyl)-benzofuran-2-carboxylic acid 
• 170799-20-9 4-(2-Methoxy-phenyl)-2-oxo-2H-chromene-3-carboxylic acid ethyl ester 
• 678967-04-9 (2-(benzyloxy)-phenyl)(2-methoxyphenyl)methanone 
• 922192-89-0 [2-but-3-enyloxyphenyl](2-methoxyphenyl)methanone 
• 62378-28-3 3-(o-methoxyphenyl)-2-phenylbenzo[b]furan 
• 678967-05-0 2-benzyloxy-2'-methoxybenzophenone hydrazide 
• 753501-20-1 1,2-bis(2-benzyloxyphenyl)-bis(2-methoxyphenyl)ethene 
• 170799-22-1 4-(2-Methoxy-phenyl)-2-oxo-2H-chromene-3-carboxylic acid 
• 1027728-08-0 3-Isocyanato-4-(2-methoxy-phenyl)-chromen-2-one 
• 1218818-81-5 3-[2'-methoxyphenyl]-1,2-benzisoxazole 
• 1316277-28-7 3-[2'-methoxyphenyl]-1,2-benzisoxazole 2-oxide 

Relevant articles and documents

Aerobic Copper-Catalyzed Salicylaldehydic Cformyl?H Arylations with Arylboronic Acids

We report a challenging copper-catalyzed Cformyl?H arylation of salicylaldehydes with arylboronic acids that involves unique salicylaldehydic copper species that differ from reported salicylaldehydic rhodacycles and palladacycles. This protocol has high chemoselectivity for the Cformyl?H bond compared to the phenolic O?H bond involving copper catalysis under high reaction temperatures. This approach is compatible with a wide range of salicylaldehyde and arylboronic acid substrates, including estrone and carbazole derivatives, which leads to the corresponding arylation products. Mechanistic studies show that the 2-hydroxy group of the salicylaldehyde substrate triggers the formation of salicylaldehydic copper complexes through a CuI/CuII/CuIII catalytic cycle.

Efficient visible-light photocatalytic aerobic oxidation of cyclic sulfamides to imines

A highly efficient photocatalytic aerobic oxidation of cyclic sulfamides to synthesize cyclic N-sulfonyl imines with Ir(ppy)2(dtbpy)PF6 as photocatalyst is reported. These environmentally friendly transformations exihibit good to excellent isolated yields and good generality with respect to both five-membered and six-membered cyclic sulfamides.

Ceric Ammonium Sulfate (CAS) Mediated Oxidations of Benzophenones Possessing a Phenolic Substituent for the Synthesis of Xanthones and Related Products

Work previously published by our group described novel methodology for the synthesis of xanthones and related products from phenolic benzophenones in a reaction mediated by ceric ammonium sulfate (CAS). In this paper we further explore this novel reaction by subjecting an additional set of phenolic benzophenones to CAS to afford a range of compounds, including xanthones, 9H-xanthen-2,9(4aH)-diones, 3H-spiro[benzofuran-2,1′-cyclohexa[2,5]diene]-3,4′-diones, and biaryl compounds. A comparison of these reactions with the more commonly used oxidant ceric ammonium nitrate (CAN) was also conducted. Based on these results, greater insight into the reaction mechanism has been gained. In addition, the conversion of the synthesized xanthen-2,9(4aH)-diones to xanthones by treatment with sodium dithionite is described.