21172-31-6

Basic information

• Product Name: 2-(3-(TRIFLUOROMETHYL)PHENYL)ACETALDEHYDE
• Synonyms: 2-(3-(TRIFLUOROMETHYL)PHENYL)ACETALDEHYDE;3-trifluoromethylphenylacetaldehyde
• CAS NO: 21172-31-6
• Molecular Formula: C₉H₇F₃O
• Molecular Weight: 188.1464896
• Mol File: 21172-31-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 199.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.229±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 2-(3-(TRIFLUOROMETHYL)PHENYL)ACETALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(TRIFLUOROMETHYL)PHENYL)ACETALDEHYDE(21172-31-6)
• EPA Substance Registry System: 2-(3-(TRIFLUOROMETHYL)PHENYL)ACETALDEHYDE(21172-31-6)

Safety Data

• Hazardous Substances Data: 21172-31-6(Hazardous Substances Data)

Usage

General Description

2-(3-(Trifluoromethyl)phenyl)acetaldehyde, also known as TFPAA, is a chemical compound with the molecular formula C9H7F3O. It is a colorless liquid with a pungent, fruity odor and is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals. TFPAA is also utilized as a flavor and fragrance ingredient in the food and beverage industry. It is known for its strong oxidizing properties and is considered to be mildly hazardous if ingested, inhaled, or absorbed through the skin. Due to its potential health risks, TFPAA should be handled and stored with caution in a controlled environment.

Upstream product

• 30934-60-2 2-[(3-trifluoromethyl)benzyl]-1,3-dioxolane 
• 455-01-6 2-[3-(trifluoromethyl)phenyl]ethanol 
• 402-24-4 3-(trifluoromethyl)styrene 
• 351-35-9 3-(trifluoromethyl)phenylacetic acid 
• 21172-30-5 m-Trifluormethylphenyl-acetaldehyd-semicarbazon 
• 62451-84-7 (3-trifluoromethyl-phenyl)-acetic acid methyl ester 
• 2338-76-3 3-trifluoromethylphenylacetonitrile 
• 705-29-3 3-Trifluoromethylbenzyl chloride 

Downstream Products

• 1190234-54-8 ethyl 5-(trifluoromethyl)-1-(4-{3-[3-(trifluoromethyl)phenyl]prop-1-ene-1-yl}-1,3-thiazol-2-yl)-1H-pyrazole-4-carboxylate 
• 1356862-22-0 C₂₅H₃₀F₄N₂O 
• 1580466-00-7 N¹,N¹-dimethyl-N³-(3-(trifluoromethyl)phenethyl)propane-1,3-diamine 
• 862205-52-5 {4-methyl-2-oxo-1-[2-(3-trifluoromethylphenyl)ethylamino]-1,2-dihydro-pyridin-3-yl}acetic acid methyl ester 
• 63035-57-4 meso-1,4-Bis(3-trifluormethylphenyl)-2,3-butandiol 
• 63035-58-5 1,4-Bis-(3-trifluormethyl-phenyl)-2-butanol 
• 433230-53-6 (3-{(4R,5S)-2-Acetoxy-4-hydroxy-5-[(E)-(S)-3-hydroxy-4-(3-trifluoromethyl-phenyl)-but-1-enyl]-cyclopent-1-enylsulfanyl}-propylsulfanyl)-acetic acid methyl ester 
• 586961-59-3 2-(3-(trifluoromethyl)phenyl)cyclohexan-1-one 
• 586961-57-1 1-(3-trifluoromethylphenyl)-5-hexen-2-one 
• 838826-73-6 1-(3-trifluoromethylphenyl)-6-hepten-2-one 
• 30934-66-8 1-phenyl-2-<3-(trifluoromethyl)phenyl>-1-ethanone 
• 586961-78-6 1-(3-trifluoromethylphenyl)-5-hexen-2-ol 
• 63035-56-3 cis-1,4-Bis-(3-trifluormethylphenyl)-2-buten 
• 237763-16-5 1-phenyl-2-(3-(trifluoromethyl)phenyl)ethan-1-ol 

Relevant articles and documents

PIPERIDINE-2,6-DIONES AS SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE

Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, and tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containin

Maleimide-assisted anti-Markovnikov Wacker-type oxidation of vinylarenes using molecular oxygen as a terminal oxidant

Arylacetaldehydes were successfully synthesized by the anti-Markovnikov Wacker-type oxidation of vinylarenes using 1 atm O2 as a terminal oxidant under mild conditions. Electron-deficient alkenes, such as maleic anhydride and maleimides, were effective additives and would operate as ligands to stabilize the Pd(0) species during the reaction.

N-Propynyl analogs of β-phenylethylidenehydrazines: Synthesis and evaluation of effects on glycine, GABA, and monoamine oxidase

A group of β-phenylethylidenehydrazines possessing a variety of substituents (Me, OMe, Cl, F, and CF3) at the ortho-, meta-, or para-positions of the phenyl ring, in conjunction with either a N-bis-(2-propynyl) or a N-mono-(2-propynyl) moiety, were synthesized and compared to the novel neuroprotective drug β-phenylethylidenehydrazine (PEH) with regard to their ability to inhibit the enzymes GABA-transaminase (GABA-T) and monoamine oxidase (MAO)-A and -B in vitro in brain tissue. Two of the analogs synthesized (mono- and bis-N-propynylPEH) were also studied ex vivo in rats to compare their effects to those of PEH with regard to ability to inhibit GABA-T and MAO and to change brain levels of several important amino acids. Unlike PEH, none of the new drugs inhibited GABA-T in vitro at 10 or 100 μM, and all of the drugs (including PEH) were poor inhibitors (at 10 μM) of MAO-A and -B in vitro. The two analogs studied ex vivo inhibited GABA-T to a lesser extent than PEH, unlike PEH that did not elevate brain levels of GABA, and inhibited MAO-A and -B more potently than PEH. Interestingly, unlike PEH, the two analogs caused marked increases in brain levels of glycine; because of the current interest in drugs that increase glycine availability in the brain as potential antipsychotic drugs, these two analogs now warrant further investigation.