21401-55-8Relevant articles and documents
A Ratiometric Two-Photon Fluorescent Probe for Tracking Lysosomal ATP: Direct In Cellulo Observation of Lysosomal Membrane Fusion Processes
Jun, Yong Woong,Wang, Taejun,Hwang, Sekyu,Kim, Dokyoung,Ma, Donghee,Kim, Ki Hean,Kim, Sungjee,Jung, Junyang,Ahn, Kyo Han
, p. 10142 - 10147 (2018)
Vesicles exchange their contents through membrane fusion processes, kiss-and-run and full-collapse fusion. Indirect observation of these fusion processes using artificial vesicles enhanced our understanding on the molecular mechanisms involved. Direct observation of the fusion processes in a real biological system, however, remains a challenge owing to many technical obstacles. We report a ratiometric two-photon probe offering real-time tracking of lysosomal ATP with quantitative information for the first time. By applying the probe to two-photon live-cell imaging, the lysosomal membrane fusion process in cells has been directly observed and the concentration of its content, lysosomal ATP, has been measured. Results show that the kiss-and-run process between lysosomes proceeds through repeated transient interactions with gradual content mixing, whereas the full-fusion process occurs at once. Furthermore, it is confirmed that both the fusion processes proceed with conservation of the content. Such a small-molecule probe exerts minimal disturbance and hence has potential for studying various biological processes associated with lysosomal ATP.
A Photoexcitation-Induced Twisted Intramolecular Charge Shuttle
Chi, Weijie,Qiao, Qinglong,Lee, Richmond,Liu, Wenjuan,Teo, Yock Siong,Gu, Danning,Lang, Matthew John,Chang, Young-Tae,Xu, Zhaochao,Liu, Xiaogang
, p. 7073 - 7077 (2019)
Charge transfer and separation are important processes governing numerous chemical reactions. Fundamental understanding of these processes and the underlying mechanisms is critical for photochemistry. Herein, we report the discovery of a new charge-transfer and separation process, namely the twisted intramolecular charge shuttle (TICS). In TICS systems, the donor and acceptor moieties dynamically switch roles in the excited state because of an approximately 90° intramolecular rotation. TICS systems thus exhibit charge shuttling. TICSs exist in several chemical families of fluorophores (such as coumarin, BODIPY, and oxygen/carbon/silicon–rhodamine), and could be utilized to construct functional fluorescent probes (i.e., viscosity- or biomolecule-sensing probes). The discovery of the TICS process expands the current perspectives of charge-transfer processes and will inspire future applications.
Effect of solvent nature on spectral properties of blue-emitting meso-propargylamino-BODIPY
Guseva, Galina B.,Ksenofontov, Alexander A.,Antina, Elena V.,Berezin, Mikhail B.,Vyugin, Anatoliy I.
, p. 194 - 203 (2019)
The spectral and luminescent properties of meso?propargylamino?boron (III) dipyrromethenate (BODIPY 1) were studied in a wide range of organic solvents of different polarities, electron- and proton-donating abilities. Effect of organic solvents on the properties of the BODIPY 1 spectral characteristics was analyzed in details. It was shown that the fluorescence of BODIPY 1 is characterized by a high sensitivity to the nature of the solvent. It was found that the complex, which emits in the blue-green region (433–486 nm), has a high quantum yield of fluorescence (~100%) in non-polar media (cyclohexane, benzene, toluene), while in proton- and especially electron donor media, sharp fluorescence quenching (2.2–31.2 times) of the dye is observed. For a better understanding of the spectral analysis results, a quantum-chemical analysis of the molecular structure, electronic structure, and spectral characteristics of BODIPY 1 was carried out. For the first time, it was shown that BODIPY 1 fluorescence quenching in proton and electron donor media is caused by the formation of a supramolecular dye complex due to specific interactions of solvent molecules with atoms of the meso?propargylamine group. Due to practically useful spectral properties, including the sensitivity of the fluorescence to the nature of the media, BODIPY 1 is recommended as a new effective fluorescent sensor of specific electron and proton donor molecules.
A BODIPY-based reactive probe for ratiometric fluorescence sensing of mercury ions
Kim, Dokyoung,Yamamoto, Koji,Ahn, Kyo Han
, p. 5279 - 5282 (2012)
A simple BODIPY derivative is demonstrated to fluorescently sense Hg 2+ in a ratiometric manner. The probe, an 8-methylthio-BODIPY, undergoes Hg2+-promoted hydrolysis to produce the corresponding 8-hydroxy-BODIPY, which conversion is accompanied with a large emission wavelength change. The probe can selectively detect Hg2+ over various other metal cations, with a detection limit of 1 ppb.
Triple molten porphyrin dimer covalent functionalized single-walled carbon nanotube nonlinear nano hybrid material and preparation method thereof
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Paragraph 0058-0060, (2020/12/30)
The invention relates to a triple molten porphyrin dimer covalent functionalized single-walled carbon nanotube non-linear nano hybrid material and a preparation method thereof. The non-linear nano hybrid material is formed by connecting a triple molten porphyrin dimer TFP to the surface of SWCNT through covalent bonds. Compared with the prior art, the organic-inorganic covalent functionalized nanofunctional material is prepared by connecting TFP to the surface of SWCNT through covalent bonds and the azo salt free radical addition reaction instead of simply and physically mixing the two different optical functional materials, and compared with a traditional material, the prepared material not only has enhanced nonlinear optical properties in the nanosecond visible light field, but also canconvert saturated absorption of a traditional material into anti-saturated absorption in the femtosecond near-infrared field, and has a very wide application prospect.
Pairing of α-Fused BODIPY: Towards Panchromatic n-Type Semiconducting Materials
Huaulmé, Quentin,Fall, Sadiara,Lévêque, Patrick,Ulrich, Gilles,Leclerc, Nicolas
, p. 6613 - 6620 (2019/05/07)
A chemical strategy to efficiently perform the dimerization of α-fused boron-dipyrromethene (BODIPY) is reported. The straightforward synthesis of one of these dimers is described and its properties have been investigated through UV/Vis spectroscopy, cyclic voltammetry, differential scanning calorimetry, and charge-carrier mobility measurements by using organic field-effect transistors and space–charge-limited current diodes. The results allow a chemical strategy to decrease the tendency of α-fused BODIPY to crystallize, to increase its light-harvesting properties, and to promote isotropic charge carriers transport. Moreover, the disclosed approach is also a way to maintain the deep LUMO level of α-fused BODIPY; thus making this class of materials highly desirable for optoelectronic applications.
