21419-05-6

Basic information

• Product Name: 5-phenyl-4-pyrimidinamine(SALTDATA: FREE)
• Synonyms: 5-phenyl-4-pyrimidinamine(SALTDATA: FREE);5-phenyl-4-pyrimidinamine
• CAS NO: 21419-05-6
• Molecular Formula: C₁₀H₉N₃
• Molecular Weight: 171.19856
• Mol File: 21419-05-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 348.1 °C at 760 mmHg
• Flash Point: 191.3 °C
• Appearance: /
• Density: 1.193g/cm³
• Vapor Pressure: 5.13E-05mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: 5-phenyl-4-pyrimidinamine(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenyl-4-pyrimidinamine(SALTDATA: FREE)(21419-05-6)
• EPA Substance Registry System: 5-phenyl-4-pyrimidinamine(SALTDATA: FREE)(21419-05-6)

Safety Data

• Hazardous Substances Data: 21419-05-6(Hazardous Substances Data)

Usage

General Description

5-phenyl-4-pyrimidinamine, also known as SALTDATA: FREE, is a chemical compound with the molecular formula C11H9N3. It belongs to the pyrimidinamine class of compounds and is characterized by a phenyl group attached to the fourth position of the pyrimidine ring. This chemical is commonly used in pharmaceutical research and drug development due to its potential biological activities. Its properties and uses may vary depending on the specific salt form in which it is applied. Additionally, it is important to handle this chemical with proper care and in accordance with safety regulations due to its potential hazards.

InChI:InChI=1/C10H9N3/c11-10-9(6-12-7-13-10)8-4-2-1-3-5-8/h1-7H,(H2,11,12,13)

Upstream product

• 1215-26-5 3-anilino-2-phenyl-acrylonitrile 
• 7664-41-7 ammonia 
• 77287-34-4 formamide 
• 33201-99-9 3-amino-2-phenyl-acrylonitrile 
• 5841-70-3 phenyl(formyl)acetonitrile 
• 4468-48-8 1-phenyl-1-cyanopropan-2-one 
• 4553-07-5 ethyl phenylcyanoacetate 
• 140-29-4 phenylacetonitrile 
• 34771-45-4 5-phenylpyrimidine 
• 290-87-9 1,3,5-Triazine 
• 2498-46-6 2-phenylacetamidine hydrochloride 
• 73591-08-9 3-methoxy-2-phenylacrylonitrile 
• 463-52-5 formamidine 

Downstream Products

• 27956-29-2 1-methyl-5-phenyl-1H-pyrimidin-4-one 
• 60122-80-7 4-chloro-5-phenylpyrimidine 
• 106537-87-5 3-Benzyl-4-ethoxy-9-phenyl-pyrimido[1,6-a]pyrimidin-2-one 
• 22433-69-8 5-phenylpyrimidin-4(3H)-one 
• 111677-65-7 6-Amino-5-phenylpyrimidine 1-Oxide 
• 106537-90-0 4-Ethoxy-3,9-diphenyl-pyrimido[1,6-a]pyrimidin-2-one 
• 56239-07-7 4-acetamido-5-phenylpyrimidine 
• 109113-92-0 2,6-dihydroxy-3-ethyl-4-oxo-9-phenylpyrimido<1,6-a>pyrimidine 
• 109113-89-5 4-oxo-3-ethyl-2-acetoxy-9-phenylpyrimido<1,6-a>pyrimidine 
• 109113-91-9 2,6-dihydroxy-3-methyl-4-oxo-9-phenylpyrimido<1,6-a>pyrimidine 
• 109113-88-4 4-oxo-3-methyl-2-acetoxy-9-phenylpyrimido<1,6-a>pyrimidine 
• 109113-94-2 2,6-dihydroxy-3-benzyl-4-oxo-9-phenylpyrimido<1,6-a>pyrimidine 
• 109113-93-1 2,6-dihydroxy-3-allyl-4-oxo-9-phenylpyrimido<1,6-a>pyrimidine 
• 109113-90-8 4-oxo-3-allyl-2-acetoxy-9-phenylpyrimido<1,6-a>pyrimidine 

Relevant articles and documents

Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Azadienes: Cycloaddition Reaction of Amidines with 1,3,5-Triazines

A detailed study of the scope of the amidine Diels-Alder reaction with 1,3,5-triazines is described.The thermal reaction of amidines with symmetrical 1,3,5-triazines proceeds with in situ amidine to 1,1-diaminoethene tautomerization, cycloaddition with the 1,3,5-triazine, loss of ammonia from the initial Diels-Alder adduct with imine generation, imine to enamine tautomerization, and retro Diels-Alder loss of ethyl cyanoformate to provide substituted 4-aminopyrimidines in excellent conversions.The reaction proceeds best with the amidine hydrochloride salts at intermediate reaction temperatures (90-100 deg C) in polar, aprotic solvents, is rather invariant to the ratio of dienophile-diene used (1:12:1), and is subject to triazine substituent effects characteristic of an inverse electron demand Diels-Alder reaction (R = CO2Et > R = H >> R = SCH3).Notably, the generality of the amidine cycloaddition reaction with 1,3,5-triazines which has been extended to include cyclic amidines effectively addresses the limitations of the alternative ynamine or N,O-ketene acetal dienophiles.A comparative examination of amidines, thioimidates, and imidates revealed that amidines are uniquely suited for use in this reaction cascade.

Polycyclic N hetero compounds. IV. Reactions of 4 amino 5 arylpyrimidines with dimethyl sulfoxide

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Aminomethylation in system of phenylacetonitril

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