21434-16-2Relevant articles and documents
Cu microcrystals garnished with copper nanoparticles catalyzed one-pot facile synthesis of novel 1,2,3-triazoles via click chemistry as antifungal agents
Kodasi, Barnabas,Joshi, Shrinivas D.,Kamble, Ravindra R.,Keri, Rangappa S.,Bayannavar, Praveen K.,Nesaragi, Aravind R.,Dixit, Shruti,Vootla, Shyam Kumar,Metre, Tukaram V.
, (2022/04/07)
A remarkable, efficacious, and environmental friendly one-pot procedure affianced for the synthesis of 1,2,3-triazoles by 1,3-dipolar cycloaddition of aromatic azides, terminal alkynes over Cu microcrystals (CuMCs) by click chemistry as subsequent way. The predominance of this method is green synthetic pathway, transient reaction times, facile workup, exceptional yields (87% to 90%) with excellent purity, regioselective single product formation, and eco-friendliness of the CuMCs catalyst. Docking studies manifested strong binding interactions with enzyme sterol 14-alpha-demethylase (PDB ID: 3KHM) with excellent C-score values. The antifungal screening of synthesized compounds revealed promising activity.
Microwave assisted regioselective synthesis of quinoline appended triazoles as potent anti-tubercular and antifungal agents via copper (I) catalyzed cycloaddition
Nesaragi, Aravind R.,Kamble, Ravindra R.,Bayannavar, Praveen K.,Shaikh, Saba Kauser J.,Hoolageri, Swati R.,Kodasi, Barnabas,Joshi, Shrinivas D.,Kumbar, Vijay M.
supporting information, (2021/04/12)
Quinolin-3-yl-methyl-1,2,3-triazolyl-1,2,4-triazol-3(4H)-ones 8j-v were synthesized by click chemistry as an ultimate tactic where [3 + 2] cycloaddition of azides with terminal alkynes has been evolved. Herein, we are inclined to divulge the implication and prevalence of CuSO4·5H2O and THF/water promoted [3 + 2] cycloaddition reactions. The foremost supremacy of this method are transitory reaction times, facile workup, excellent yields (88–92%) with exorbitant purity and regioselective single product formation both under conventional and microwave method. Docking studies illustrated strong binding interactions with enzyme InhA-D148G (PDB ID: 4DQU) by means of high C-score values. The anti-tubercular and antifungal screening of synthesized compounds proclaimed promising activity. The in vitro and in silico studies imply that these triazoles appended quinolines may acquire the ideal structural prerequisites for auxiliary expansion of novel therapeutic agents.
C5-Alkyl-1,3,4-Oxadiazol-2-ones Undergo Dealkylation upon Nitrogen Insertion to Form 2H-1,2,4-Triazol-3-ones: Synthesis of 1,2,4-Triazol-3-one Hybrids with Triazolothiadiazoles and Triazolothiadiazines
Kattimani, Pramod P.,Kamble, Ravindra R.,Dorababu, Atukuri,Hunnur, Raveendra K.,Kamble, Atulkumar A.,Devarajegowda
, p. 2258 - 2265 (2017/07/25)
The present study emphasizes on the dealklylation of 3-aryl-5-alkyl-2-oxo-Δ4-1,3,4-oxadiazoles when reacted with formamide resulting in the formation of 2-aryl-2H-1,2,4-triazol-3(4H)-ones as major product. Subsequent reactions of 2-aryl-2H-1,2,
