214360-73-3 Usage
Description
4-Aminophenylboronic acid pinacol ester is an almost white to light beige crystalline powder, which is a versatile reagent in organic synthesis and has a wide range of applications in various industries due to its unique chemical properties.
Uses
Used in Chemical Synthesis:
4-Aminophenylboronic acid pinacol ester is used as a reagent for the preparation of substituted 3-phenyl-4H-1-benzopyran-4-ones by reacting with iodochromones via Pd-catalyzed Suzuki-Miyaura cross-coupling reaction. This application is significant in the synthesis of complex organic molecules and pharmaceutical compounds.
Used in Analytical Chemistry:
4-Aminophenylboronic acid pinacol ester is used as a reagent for Mercury(II) detection by fluorometry with new fluorogenic indicators based on through-bond energy transfer from pentaquinone to rhodamine. This application is crucial in environmental and industrial monitoring of mercury contamination.
Used in Pharmaceutical Industry:
4-Aminophenylboronic acid pinacol ester is used as a reagent for Rhodium-catalyzed amination reactions and Palladium-catalyzed Suzuki cross-coupling to synthesize potential antitubercular and antimicrobial compounds. These applications are vital in the development of new drugs to combat tuberculosis and various microbial infections.
Used in Material Science:
4-Aminophenylboronic acid pinacol ester is used to prepare Hexaphenylbenzene derivatives as a potential bioprobe and multichannel keypad system. This application is important in the development of advanced materials for security and authentication systems.
Used in Electronics:
4-Aminophenylboronic acid pinacol ester is used to prepare Pyromellitic diimide-based polymer as a matrix for solution-processable n-channel field-effect transistors. This application is significant in the development of advanced electronic devices and materials.
Used in Polymer Science:
4-Aminophenylboronic acid pinacol ester is used to prepare Alternating copolymers of oligoarylenes and naphthalene bisimides as low band-gap semiconductors with electrochemical and spectroelectrochemical behavior. This application is crucial in the development of new materials for solar cells and other optoelectronic devices.
Used in Medical Research:
4-Aminophenylboronic acid pinacol ester is used to prepare γ-secretase modulators in the treatment of amyloid β formation. This application is important in the development of therapeutic strategies for Alzheimer's disease and other neurodegenerative disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 214360-73-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,3,6 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 214360-73:
(8*2)+(7*1)+(6*4)+(5*3)+(4*6)+(3*0)+(2*7)+(1*3)=103
103 % 10 = 3
So 214360-73-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H18BNO2/c1-11(2)12(3,4)16-13(15-11)9-5-7-10(14)8-6-9/h5-8H,14H2,1-4H3
214360-73-3Relevant articles and documents
Synthesis of a photostable near-infrared-absorbing photosensitizer for selective photodamage to cancer cells
Hsieh, Tung-Sheng,Wu, Jhen-Yi,Chang, Cheng-Chung
, p. 9709 - 9715 (2014)
A new class of near-infrared (NIR)-absorptive (>900 nm) photosensitizer based on a phenothiazinium scaffold is reported. The stable solid compound, o-DAP, the oxidative form of 3,7-bis(4-methylaminophenyl)-10H-phenothiazine, can generate reactive oxygen species (ROS, singlet oxygen and superoxide) under appropriate irradiation conditions. After biologically evaluating the intracellular uptake, localization, and phototoxicity of this compound, it was concluded that o-DAP is photostable and a potential selective photodynamic therapy (PDT) agent under either NIR or white light irradiation because its photodamage is more efficient in cancer cells than in normal cells and is without significant dark toxicity. This is very rare for photosensitizers in PDT applications. Selective PDT agent: A photostable near-infrared (NIR)-absorptive phenothiazinium derivative, o-DAP, has been successfully synthesized and demonstrated to be a potential tumor-specific NIR-absorptive (>900 nm) photosensitizer for photodynamic therapy (PDT; see figure). This compound is expected to become a PDT reagent in a solar environment.
Terphenyl based 'Turn On' fluorescent sensor for mercury
Bhalla, Vandana,Tejpal, Ruchi,Kumar, Manoj,Puri, Rajiv Kumar,Mahajan, Rakesh K.
, p. 2649 - 2652 (2009)
New terphenyl-based derivative 4 with pyrene as a fluorophore has been synthesized and examined for its cation recognition abilities toward various cations by NMR and fluorescence spectroscopy. The results show that it has very high binding affinity (log
Method for preparing amine through catalytic reduction of nitro compound by cyclic (alkyl) (amino) carbene chromium complex
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Paragraph 0015, (2021/04/17)
The cyclic (alkyl) (amino) carbene chromium complex is prepared from corresponding ligand salt, alkali and CrCl3 and used for catalyzing pinacol borane to reduce nitro compounds in an ether solvent under mild conditions to generate corresponding amine. The method for preparing amine has the advantages of cheap and accessible raw materials, mild reaction conditions, wide substrate application range, high selectivity and the like, and is simple to operate.
PERK INHIBITING PYRROLOPYRIMIDINE COMPOUNDS
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Paragraph 0136; 0137; 0138, (2021/03/05)
Provided herein are compounds of formula (I), compositions, and methods useful for inhibiting PERK and for treating related conditions diseases, and disorders.