215776-67-3

Basic information

• Product Name: 3-[4-(tert-butyl-dimethyl-silanyloxy)phenyl]propan-1-ol
• Synonyms: 3-[4-(tert-butyl-dimethyl-silanyloxy)phenyl]propan-1-ol
• CAS NO: 215776-67-3
• Molecular Weight: 266.456
• Mol File: 215776-67-3.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 3-[4-(tert-butyl-dimethyl-silanyloxy)phenyl]propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(tert-butyl-dimethyl-silanyloxy)phenyl]propan-1-ol(215776-67-3)
• EPA Substance Registry System: 3-[4-(tert-butyl-dimethyl-silanyloxy)phenyl]propan-1-ol(215776-67-3)

Safety Data

• Hazardous Substances Data: 215776-67-3(Hazardous Substances Data)

Upstream product

• 161249-56-5 3-[4-(tert-butyl-dimethyl-silanyloxy)phenyl]propionic acid methyl ester 
• 114774-39-9 3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoic acid 
• 10210-17-0 3-(4-hydroxyphenyl)propan-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 222422-33-5 tert-butyldimethyl(4-(oxiran-2-ylmethyl)phenoxy)silane 
• 123-08-0 4-hydroxy-benzaldehyde 
• 120743-99-9 p-[(tert-butyldimethylsilyl)oxy]benzaldehyde 
• 522602-18-2 ethyl 3-(4-((tert-butyl(dimethyl)silyl)oxy)phenyl)propanoate 
• 143422-89-3 (2-methylallyl)tertiobutyl-dimethylsilane 
• 501-97-3 4-hydroxyphenylpropionic acid 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 

Downstream Products

• 951377-91-6 [(3aS,4E,5S,6aR)-4-ethylidene-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl]acetic acid 3-[4-(tert-butyldimethylsilyloxy)phenyl]propyl ester 
• 433931-42-1 3-(4-(tert-butyldimethylsilyloxy)phenyl)propyl methanesulfonate 
• 287198-97-4 tert-Butyl-dimethyl-{4-[(3E,5E,7E)-10-(tetrahydro-pyran-2-yloxy)-deca-3,5,7-trienyl]-phenoxy}-silane 
• 287198-98-5 Acetic acid (3E,5E,7E)-10-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-deca-3,5,7-trienyl ester 
• 287199-02-4 (3E,5E,7E)-10-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-deca-3,5,7-trien-1-ol 
• 287198-99-6 4-((3E,5E,7E)-10-Hydroxy-deca-3,5,7-trienyl)-phenol 
• 287198-93-0 tert-butyl-[4-(4-iodo-but-3-enyl)-phenoxy]-dimethyl-silane 
• 893403-87-7 3-benzenesulfonyl-4-(3-(4-(tert-butyl(dimethyl)silyloxy)phenyl)propoxy)furoxan 

Relevant articles and documents

Transition Metal Free C-N Bond Forming Dearomatizations and Aryl C-H Aminations by in Situ Release of a Hydroxylamine-Based Aminating Agent

We outline a simple protocol that accesses directly unprotected secondary amines by intramolecular C-N bond forming dearomatization or aryl C-H amination. The method is dependent on the generation of a potent electrophilic aminating agent released by in situ deprotection of O-Ts activated N-Boc hydroxylamines.

Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

Herein, we report studies leading to the discovery of the neoseptins and a comprehensive examination of the structure-activity relationships (SARs) of this new class of small-molecule mouse Toll-like receptor 4 (mTLR4) agonists. The compounds in this class, which emerged from screening an α-helix mimetic library, stimulate the immune response, act by a well-defined mechanism (mouse TLR4 agonist), are easy to produce and structurally manipulate, exhibit exquisite SARs, are nontoxic, and elicit improved and qualitatively different responses compared to lipopolysaccharide, even though they share the same receptor.

NITRIC OXIDE DONOR NEPRILYSIN INHIBITORS

In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, R7, R8, Z, X, b, and c are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are nitric oxide donors and have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.