21730-69-8

Basic information

• Product Name: 5-(2-methoxyphenyl)methylenehydantoin
• Synonyms: 5-(2-methoxyphenyl)methylenehydantoin
• CAS NO: 21730-69-8
• Molecular Formula: C₁₁H₁₀N₂O₃
• Molecular Weight: 218.21
• Mol File: 21730-69-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.317g/cm³
• Refractive Index: 1.619
• CAS DataBase Reference: 5-(2-methoxyphenyl)methylenehydantoin(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-methoxyphenyl)methylenehydantoin(21730-69-8)
• EPA Substance Registry System: 5-(2-methoxyphenyl)methylenehydantoin(21730-69-8)

Safety Data

• Hazardous Substances Data: 21730-69-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H10N2O3/c1-16-9-5-3-2-4-7(9)6-8-10(14)13-11(15)12-8/h2-6H,1H3,(H2,12,13,14,15)/b8-6+

Upstream product

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Downstream Products

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• 861568-54-9 N-carbamoyl-2-methoxy-phenylalanine 

Relevant articles and documents

Chemoenzymatic synthesis of L-3,4-dimethoxyphenyl-alanine and its analogues using aspartate aminotransferase as a key catalyst

In this study, a chemoenzymatic synthesis method for the production of L-3,4-dimethoxyphenyl-alanine and its analogues from phenylpyruvate derivatives was developed. The aspartate aminotransferase from Escherichia coli was engineered by error prone PCR and the improved variants were identified. When 3, 4-dimethoxy phenylpyruvate was added by fed-batch on a preparative scale, L-3,4-dimethoxyphenyl-alanine was formed in 95.4% conversion and > 99% ee with the best aspartate aminotransferase variant as the catalyst. This study provided an efficient method for the production of methoxy substituted phenylalanines using the engineered aspartate aminotransferase.

Process for the preparation of D1-β-aryl amino acids

The invention relates to a process for the preparation of DL-β-aryl-amino acids of the general Formula STR1 wherein R, R1 and R2 stand for hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro or C1-4 dialkylamino; whereby in the case of monosubstituted derivatives R and R1 are hydrogen and R2 has the same meaning as stated above and can be attached to position 2, 3 or 4 related to the methylene group; in the case of disubstituted derivatives R is hydrogen and R1 and R2 have the same meaning as stated above and are attached to positions 2,3; 2,4; 2,5; 2,6; 3,4 or 3,5 related to the methylene group; in the case of trisubstituted derivatives R, R1 and R2 have the same meaning as stated above and are attached to positions 2,3,4; 2,3,5; 2,3,6; 3,4,5 or 3,4,6 related to the methylene group.