21784-73-6 Usage
Description
4-IODO-2-NITROPHENOL, with the molecular formula C6H4INO3, is a yellow crystalline solid that is insoluble in water but soluble in organic solvents. This chemical compound is primarily utilized as an intermediate in the synthesis of various organic compounds and pharmaceuticals, as well as in the production of dyes, pigments, and pesticides. Due to its toxic nature, it is crucial to handle 4-IODO-2-NITROPHENOL with care to avoid skin and eye irritation.
Uses
Used in Pharmaceutical Industry:
4-IODO-2-NITROPHENOL is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications.
Used in Organic Compounds Synthesis:
4-IODO-2-NITROPHENOL serves as a key intermediate in the synthesis of a range of organic compounds, playing a vital role in the creation of diverse chemical products.
Used in Dye and Pigment Production:
4-IODO-2-NITROPHENOL is utilized in the production of dyes and pigments, providing color and functionality to various products in industries such as textiles, plastics, and paints.
Used in Pesticide Manufacturing:
4-IODO-2-NITROPHENOL is employed in the manufacturing process of pesticides, contributing to the development of effective solutions for pest control in agriculture and other sectors.
Check Digit Verification of cas no
The CAS Registry Mumber 21784-73-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,7,8 and 4 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 21784-73:
(7*2)+(6*1)+(5*7)+(4*8)+(3*4)+(2*7)+(1*3)=116
116 % 10 = 6
So 21784-73-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H4INO3/c7-4-1-2-6(9)5(3-4)8(10)11/h1-3,9H
21784-73-6Relevant articles and documents
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Roberts,de Worms,Clark
, p. 199 (1935)
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Ruthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H Insertion: Synthesis of Benzofused Six-Membered Azaheterocycles
Padín, Damián,Saá, Carlos,Varela, Jesús A.
supporting information, (2020/03/30)
The Cp*RuCl-based catalyst enables expedient access to a variety of benzofused six-membered azaheterocycles from unprotected o-alkynylanilines and trimethylsilyldiazomethane through an unprecedent tandem carbene/alkyne metathesis/N-H insertion reaction. The transformation takes place under mild reaction conditions (room temperature, 15 min) and with excellent functional group tolerance. The synthetic utility of the final products and a mechanistic rationale are also discussed.
Iodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Br?nsted Acidic NO2+ Generation
Juárez-Ornelas, Kevin A.,Jiménez-Halla, J. Oscar C.,Kato, Terumasa,Solorio-Alvarado, César R.,Maruoka, Keiji
supporting information, p. 1315 - 1319 (2019/03/07)
The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Br?nsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.
