21847-98-3

Basic information

• Product Name: 1-Pentanone, 4-methyl-1-(4-methylphenyl)-
• CAS NO: 21847-98-3
• Molecular Formula: C13H18O
• Molecular Weight: 190.285
• Mol File: 21847-98-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-Pentanone, 4-methyl-1-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pentanone, 4-methyl-1-(4-methylphenyl)-(21847-98-3)
• EPA Substance Registry System: 1-Pentanone, 4-methyl-1-(4-methylphenyl)-(21847-98-3)

Safety Data

• Hazardous Substances Data: 21847-98-3(Hazardous Substances Data)

Upstream product

• 1757-42-2 3-methyl-cyclopentanone 
• 4463-41-6 2-(p-tolyl)-1,3,2-dioxaborinane 
• 513-38-2 Isobutyl iodide 
• 766-97-2 4-n-methylphenylacetylene 
• 4548-78-1 (3-methylbutyl)magnesium bromide 
• 104-85-8 para-methylbenzonitrile 
• 22422-21-5 4'-methyl-3-chloropropiophenone 
• 1539-32-8 4-isopropyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 874-60-2 4-methyl-benzoyl chloride 
• 38136-29-7 4-methylvaleroyl chloride 
• 108-88-3 toluene 
• 104-87-0 4-methyl-benzaldehyde 
• 73177-66-9 4-methyl-1-(4-methylphenyl)-1-pentanol 

Downstream Products

• 104455-10-9 2-Bromo-4-methyl-1-(4-methylphenyl)pentan-1-one 

Relevant articles and documents

Preparation method of diabetes-treating medicine, namely ipragliflozin or derivative thereof

The invention provides a preparation method of a diabetes-treating medicine, namely ipragliflozin or a derivative thereof. According to the preparation method, alpha-O-alkenyl sulfone is used as an electrophilic reagent for the Suzuki-Miyaura coupling reaction; the reaction raw material alpha-O-alkenyl sulfone is simple to prepare and stable in structure, and can overcome the defects of instability, preparation difficulty and the like when organic halide and sulfonic acid are used as electrophilic reagents for the Suzuki-Miyaura coupling reaction. Meanwhile, the reaction are mild in reaction conditions, compatible with a wide range of heterocyclic rings and various functional groups, high in yield and capable of realizing large-scale process production. Since alpha-O-alkenyl sulfone is used as the electrophilic reagent for the Suzuki-Miyaura coupling reaction, high-yield generation of aryl glucoside and open-chain alkenyl ether can be realized, medicines for treating type 2 diabetes mellitus, namely ipragliflozin and 2-deoxyipragliflozin can also be prepared, and the application scope of the preparation method is wide.

Mn-Enabled Radical-Based Alkyl-Alkyl Cross-Coupling Reaction from 4-Alkyl-1,4-dihydropyridines

Highly efficient alkylation of β-chloro ketones and their derivatives was achieved by means of domino dehydrochlorination/Mn-enabled radical-based alkyl-alkyl cross-coupling reaction. In situ-generated α,β-unsaturated ketones and their analogues were identified as the reaction intermediates. Known bioactive compounds, such as melperone and azaperone, could be easily prepared from β-chloropropiophenone in two steps.

Regioselective Vinylation of Remote Unactivated C(sp3)?H Bonds: Access to Complex Fluoroalkylated Alkenes

Regioselective incorporation of a particular functional group into aliphatic sites by direct activation of unreactive C?H bonds is of great synthetic value. Despite advances in radical-mediated functionalization of C(sp3)?H bonds by a hydrogen-atom transfer process, the site-selective vinylation of remote C(sp3)?H bonds still remains underexplored. Reported herein is a new protocol for the regioselective vinylation of unactivated C(sp3)?H bonds. The remote C(sp3)?H activation is promoted by a C-centered radical instead of the commonly used N and O radicals. The reaction possesses high product diversity and synthetic efficiency, furnishing a plethora of synthetically valuable E alkenes bearing tri-/di-/mono-fluoromethyl and perfluoroalkyl groups.