220438-32-4Relevant articles and documents
Accessing Aliphatic Amines in C-C Cross-Couplings by Visible Light/Nickel Dual Catalysis
Badir, Shorouk O.,Dong, Weizhe,Molander, Gary A.,Zhang, Xuange
supporting information, p. 4250 - 4255 (2021/06/27)
A general aminoalkylation of aryl halides was developed, overcoming intolerance of free amines in nickel-mediated C-C coupling. This transformation features broad functional group tolerance and high efficiency. Taking advantage of the fast desilylation of α-silylamines upon single-electron transfer (SET) facilitated by carbonate, α-amino radicals are generated regioselectively, which then engage in nickel-mediated C-C coupling. The reaction displays high chemoselectivity for C-C over C-N bond formation. Highly functionalized pharmacophores and peptides are also amenable.
Building addressable libraries: Site-selective formation of an N-acyliminium ion intermediate
Kesselring, David,Maurer, Karl,Moeller, Kevin D.
supporting information; experimental part, p. 2501 - 2504 (2009/05/27)
(Chemical Equation Presented) A strategy for site-selectively generating reactive N-acyliminium ion intermediates on a microelectrode array has been developed. The route capitalizes on the use of an electroauxiliary for building a methoxylated amino acid
Building functionalized peptidomimetics: New electroauxiliaries and the use of a chemical oxidant for introducing N-acyliminium ions into peptides
Sun, Haizhou,Moeller, Kevin D.
, p. 3189 - 3192 (2007/10/03)
(Matrix presented) The removal of electroauxiliaries from peptide substrates with chemical oxidants has been examined as a method for inserting N-acyliminium ions into the peptides. To this end, it was found that both 4-methoxyphenyldimethylsilyl and 2,4-
