220467-31-2

Basic information

• Product Name: N-(benzyloxymethyl)-2-chloroindole-3-carbaldehyde
• Synonyms: N-(benzyloxymethyl)-2-chloroindole-3-carbaldehyde
• CAS NO: 220467-31-2
• Molecular Weight: 299.757
• Mol File: 220467-31-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(benzyloxymethyl)-2-chloroindole-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: N-(benzyloxymethyl)-2-chloroindole-3-carbaldehyde(220467-31-2)
• EPA Substance Registry System: N-(benzyloxymethyl)-2-chloroindole-3-carbaldehyde(220467-31-2)

Safety Data

• Hazardous Substances Data: 220467-31-2(Hazardous Substances Data)

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 5059-30-3 2-chloroindole-3-carboxaldehyde 

Downstream Products

• 220467-32-3 N-(benzyloxymethyl)-2-ethenylindole-3-carbaldehyde 
• 220467-33-4 N-(benzyloxymethyl)-2-ethenyl-3-(1-hydroxyprop-2-yn-1-yl)indole 
• 220467-35-6 N-(benzyloxymethyl)-4-(benzyloxymethyloxy)-3-methylcarbazole 
• 220467-34-5 N-(benzyloxymethyl)-3-[1-(benzyloxymethyloxy)prop-2-yn-1-yl]-2-ethenylindole 

Relevant articles and documents

Novel syntheses of murrayaquinone A and furostifoline through 4-oxygenated carbazoles by allene-mediated electrocyclic reactions starting from 2-chloroindole-3-carbaldehyde

The formal total synthesis of murrayaquinone A (1) and the total synthesis of furostifoline (5) were completed by the construction of 4-oxygenated 3-methylcarbazoles 7 based on a new type of electrocyclic reaction through 2-alkenyl-3-allenylindole intermediates 8 derived from the 2-alkenyl-3-propargylindoles 9, starting from 2-chloroindole-3-carbaldehyde (11). The N, O-bisbenzyloxymethyl group of 16c and 22 underwent a Birch reduction followed by treatment with Triton B to produce the known 4-hydroxy-3-methylcarbazole (7a) and 4-hydroxy-3-methylfuro[3, 2-a]carbazole (7b) as precursors of murrayaquinone A (1) and furostifoline (5), respectively. The trifluoromethanesulfonyloxy-3-methylfuro[3, 2-a]carbazole (24), prepared from 7b, was subjected to reductive cleavage to provide furostifoline (5).