220877-46-3Relevant articles and documents
Imide and lactam derivatives of N-benzylpyroglutamyl-L-phenylalanine as VCAM/VLA-4 antagonists
Tilley, Jefferson W,Kaplan, Gerry,Rowan, Karen,Schwinge, Virginia,Wolitzky, Barry
, p. 1 - 4 (2001)
A series of imides and lactams derived from 4-amino-N-benzylpyroglutamyl-L-phenylalanine was prepared and evaluated for activity as VCAM/VLA-4 antagonists. Imides were more potent than the corresponding lactams; several had subnanomolar IC50s in an ELISA based assay and were also highly effective at blocking VLA-4 expressing Ramos cell binding to VCAM coated plates. (C) 2000 Elsevier Science Ltd.