2213-81-2Relevant articles and documents
Method for synthesizing 1,3-dinitrohalobenzene compound
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Paragraph 0096; 0099; 0103; 0112; 0115-0120; 0121; 0124, (2019/07/16)
The invention provides a method for synthesizing a 1,3-dinitrohalobenzene compound. The method comprises the following steps that A) a halogenated benzene compoundand mixed acid of nitric acid and sulfuric acid are subjected to a first nitrification reaction in a first-stage continuous flow microreactor, and oil-water separation is conducted to obtain a mononitrohalobenzene compound and first waste acid; B) the mononitrohalobenzene compound is drained into a second-stage continuous flow microreactor, a second nitrification reaction is conducted with the mixed acid of the nitric acid and the sulfuric acid, a generated nitration mixture is quenched at the outlet of the second-stage continuous flow microreactor, and filtering is conducted to obtain the 1,3-dinitrohalobenzene compound and second waste acid; C) the second waste acid is recycled to the first-stage continuous flow microreactor, a third nitration reaction with the halobenzene compound is carried out, the oil-water separation is conducted to obtain the mononitrohalobenzene compound and third waste acid, and steps B) and C) are repeated; the halobenzene compound has a structure shown in the formula I. The reaction time is short, the waste acid is less, and continuous production is achieved.
CYTOKINE INHIBITORS
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Page/Page column 123, (2008/12/07)
The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines, such as for example arthritis, pain, cardiovascular disease and cancer.
Method for inhibiting the growth of tobacco suckers
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, (2008/06/13)
The growth of tobacco suckers in tobacco plants is inhibited by applying to the tobacco plants an effective amount of a substituted 2,6-dinitroaniline alone or in combination with a surfactant.