2226-72-4

Basic information

• Product Name: 5'-azacytidine 5'-monophosphate
• Synonyms: 5'-azacytidine 5'-monophosphate;1,3,5-Triazin-2(1H)-one, 4-amino-1-(5-o-phosphono-beta-D-ribofuranosyl)-;5-Azacytidine 5'-Monophosphate 60%;4-AMino-1-(5-O-phosphono-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one;4-AMino-1-β-D-ribofuranosyl- s-triazin-2(1H)-one 5'-Phosphate
• CAS NO: 2226-72-4
• Molecular Formula: C8H13N4O8P
• Molecular Weight: 324.18
• Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Metabolites & Impurities;Nucleotides;Phosphorylating and Phosphitylating Agents;Carbohydrates & Derivatives, Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Phosphorylating and Phosphitylating Agents
• Mol File: 2226-72-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: >127°C (dec.)
• Boiling Point: 668.5 °C at 760 mmHg
• Flash Point: 358.1 °C
• Appearance: /
• Density: 2.33 g/cm³
• Vapor Pressure: 4.02E-22mmHg at 25°C
• Refractive Index: 1.833
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Water (Slightly)
• PKA: 1.86±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 5'-azacytidine 5'-monophosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-azacytidine 5'-monophosphate(2226-72-4)
• EPA Substance Registry System: 5'-azacytidine 5'-monophosphate(2226-72-4)

Safety Data

• Hazardous Substances Data: 2226-72-4(Hazardous Substances Data)

Usage

Description

5'-azacytidine 5'-monophosphate is a nucleoside monophosphate derivative of 5-azacytidine, a demethylating agent used in the treatment of certain cancers. It is a white to off-white solid and is a metabolite of 5-azacytidine, which means it is a product of the body's metabolism of the parent compound. 5'-azacytidine 5'-monophosphate also contains sodium chloride and water.

Uses

Used in Pharmaceutical Industry:
5'-azacytidine 5'-monophosphate is used as an active pharmaceutical ingredient for the development of cancer treatments. It is particularly effective in the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) due to its demethylating properties, which help to reactivate silenced genes in cancer cells and restore normal cell function.
Used in Research Applications:
In the field of scientific research, 5'-azacytidine 5'-monophosphate is used as a research tool for studying the effects of DNA methylation on gene expression and cellular processes. It is also utilized in the development of new drugs and therapies targeting epigenetic modifications, which play a crucial role in various diseases, including cancer.
Used in Drug Delivery Systems:
Similar to gallotannin, 5'-azacytidine 5'-monophosphate can be incorporated into drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes. These systems may include nanoparticles, liposomes, or other advanced drug carriers designed to enhance the efficacy and safety of the compound in treating specific conditions.

InChI:InChI=1/C8H13N4O8P/c9-3-1-2-12(8(15)10-3)7-5(14)4(13)6(19-7)11-20-21(16,17)18/h1-2,4-7,11,13-14H,(H2,9,10,15)(H2,16,17,18)/t4-,5+,6-,7+/m0/s1