223251-25-0 Usage
Description
4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL, also known as 1-[2-[4-(Chloromethyl)phenoxy]ethyl]hexahydro-1H-azepine Hydrochloride, is a synthetic intermediate with significant applications in the pharmaceutical industry. It is characterized by its unique chemical structure, which includes an azepane ring and a benzyl chloride group, making it a versatile compound for various synthetic processes.
Uses
Used in Pharmaceutical Industry:
4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL is used as a synthetic intermediate for the synthesis of Bazedoxifene (B129250), a nonsteroidal selective estrogen receptor modulator (SERM). It plays a crucial role in the development of this medication, which is utilized for the treatment of osteoporosis and other related conditions.
As an Antiosteoporotic Agent:
4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL is used as a key component in the development of antiosteoporotic drugs. Its incorporation into the synthesis of Bazedoxifene contributes to the drug's effectiveness in combating osteoporosis, a condition characterized by the weakening of bones and an increased risk of fractures.
Check Digit Verification of cas no
The CAS Registry Mumber 223251-25-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,2,5 and 1 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 223251-25:
(8*2)+(7*2)+(6*3)+(5*2)+(4*5)+(3*1)+(2*2)+(1*5)=90
90 % 10 = 0
So 223251-25-0 is a valid CAS Registry Number.
223251-25-0Relevant articles and documents
Compound and preparation method and application thereof
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, (2020/12/15)
The invention relates to the field of medicinal chemistry and pharmacotherapeutics, in particular to a bazedoxifene analog compound and a preparation method thereof, application of the bazedoxifene analog compound in a GP130 small molecule inhibitor and t
Preparation method of 1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride
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, (2017/12/27)
A preparation method of 1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride comprises the steps of alkylation, substitution, reduction and chlorination. The preparation method for industrially producing the1-(2-(4-(chloromethyl)phenoxy)ethyl)azacycloheptane hydrochloride allows the final product to be produced from cycloheximide as raw material through alkylation, substitution, reduction and chlorination, the total yield of the four steps reaches about 70%, and the purity is 99%. The method also has the advantages of easiness in obtaining of the reaction raw material, mild conditions, simplicity in treatment, and high yield, and is a method suitable for industrial production.
PREPARATION OF BAZEDOXIFENE AND ITS SALTS
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, (2011/04/13)
Processes for preparing bazedoxifene and its pharmaceutically acceptable salts, substantially free from process related impurities and process intermediates.