22344-77-0

Basic information

• Product Name: 7-Chloro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
• Synonyms: 7-Chloro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one;7-chloro-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one;7-chloro-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
• CAS NO: 22344-77-0
• Molecular Formula: C₁₀H₁₀ClNO
• Molecular Weight: 195.6455
• Mol File: 22344-77-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 161-163℃
• Boiling Point: 372.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.234
• PKA: 14.26±0.20(Predicted)
• CAS DataBase Reference: 7-Chloro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(22344-77-0)
• EPA Substance Registry System: 7-Chloro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(22344-77-0)

Safety Data

• Hazardous Substances Data: 22344-77-0(Hazardous Substances Data)

Upstream product

• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 160938-18-1 1-iodo-5-chloro-2-nitrobenzene 
• 22246-45-3 1,3,4,5-Tetrahydro-7-nitro-2H-benzazepin-2-on 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 68253-36-1 1-tetralone oxime 
• 22245-92-7 7-Amino-1,3,4,5-tetrahydro-2H-benzazepin-2-on 

Downstream Products

• 80452-55-7 7-chloro-1,3,4,5-tetrahydro-2H-1-benzazepine-2,5-dione 
• 313673-94-8 7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepine 
• 879999-67-4 7-chloro-1-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 879999-68-5 7-chloro-1-[2-nitrophenylsulfonyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 87379-36-0 10-chloro-5,7-dihydro-2-methyl-7-phenylpyrimido<5,4-d>benzazepin-6(6H)-one 
• 960207-27-6 C₂₇H₃₃N₃O₄ClF 

Relevant articles and documents

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model

Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent and sel

Synthesis of tetrahydrobenzazepinesulfonamides and their rearrangement to diarylsulfones

A new class of diarylsulfones, in which tetrahydrobenzazepine comprises one of the aromatic moieties, has been synthesized via the acid-catalyzed rearrangement of several substituted benzazepinesulfonamides. The rearrangement is normally ortho but in at l

Synthesis of 7-phenylpyrimido[5,4-d][1]benzazepin-2-ones

The syntheses of the 7-phenylpyrimido[5,4-d][1]benzazepin-2-ones 3, 4, and 5 are described. The 7-phenyl group was introduced by phenylation of the lactam nitrogen in 10, 13 and 16 respectively. One of these compounds, 5, showed moderate activity as a CNS agent.