223673-34-5

Basic information

• Product Name: (alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol
• Synonyms: (alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol;BenzeneMethanol, a-[[[2-(4-nitrophenyl)ethyl]aMino]Methyl]-, (aR)-;BenzeneMethanol, -[[[2-(4-nitrophenyl)ethyl]aMino]Methyl]-, (R)-;(R)--[[[2-(4-nitrophenyl)ethyl]aMino]Methyl]-BenzeneMethanol;Mirabegron INT 2;(alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethan;(R)-2-(4-nitrophenethylamino)-1-phenylethanol;(R)-2-((4-nitrophenethyl)amino)-1-phenylethan-1-ol
• CAS NO: 223673-34-5
• Molecular Formula: C16H18N2O3
• Molecular Weight: 286.32572
• Mol File: 223673-34-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 472.5±24.0 °C(Predicted)
• Appearance: /
• Density: 1.219
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 13.95±0.20(Predicted)
• CAS DataBase Reference: (alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol(223673-34-5)
• EPA Substance Registry System: (alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol(223673-34-5)

Safety Data

• Hazardous Substances Data: 223673-34-5(Hazardous Substances Data)

Usage

General Description

The chemical compound "(alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol" is an organic compound that is a derivative of benzenemethanol. It has a nitrophenyl group attached to an ethylamino group, which in turn is attached to the benzenemethanol structure. (alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol is a chiral molecule with an alphaR configuration. It may have potential applications in pharmaceuticals and organic synthesis due to its complex structure and potential reactivity. However, further research and testing are necessary to fully understand its properties and potential uses.

Upstream product

• 521284-19-5 (2R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylethanamide 
• 29968-78-3 2-(4-nitrophenyl)ethylamine monohydrochloride 
• 555-21-5 4-Nitrophenylacetonitrile 
• 1460-05-5 p-nitrophenylacetaldehyde 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 611-71-2 (R)-Mandelic Acid 
• 24954-67-4 2-(p-nitrophenyl)ethylamine 
• 70-11-1 α-bromoacetophenone 
• 20780-53-4 (R)-Styrene oxide 

Downstream Products

• 521284-21-9 (R)-2-[[2′-(4-nitrophenyl)ethyl]amino]-1-phenylethanol hydrochloride 

Relevant articles and documents

Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process

A continuous-flow reduction of (R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylacetamide, involved in the synthetic pathway of Mirabegron, has been developed. This study demonstrated the possibility to safely handling BH3 complexes within microfluidic reactors using 2-MeTHF as greener alternative to traditional solvents, and without requiring any additive such as DMI. In addition, NMR and HPLC purity analysis revealed that the sole by-product of this process is the diamine 3, which wouldn't affect the following synthetic steps towards Mirabegron.

A method for preparing milamila beilong

The invention discloses a method for preparing milamila beilong, relates to the technical field of pharmaceutical, comprising the following steps: R - mandelic acid and P ethylamine under high-temperature to amide condensation reaction, to obtain the intermediate (R)- 2 - hydroxy - N - (4 - nitrophenyl ethyl) - 2 - phenyl acetamide; then diisobutyl hydrogenated aluminum reducing amide carbonyl, to obtain the intermediate (R)- 2 - ((4 - nitrophenyl ethyl) amino) - 1 - phenyl ethanol hydrochloride; ammonium formate - Pd/C by nitro reduction system, to obtain the intermediate (R)- 2 - ((4 - amino ethyl) amino) - 1 - phenyl ethanol; finally with the amino thiazole acetic acid to generate a condensation reaction, to obtain milamila beilong. The invention prepared milamila beilong purity is good, high yield, synthetic line few steps, conditions is mild and controllable, the operation is simple, low cost, and is suitable for industrial production, and with extensive prospect and industrial application value.

Nitrogen heterocyclic ring group substituted amide derivative and application thereof

The invention discloses a nitrogen heterocyclic ring group substituted amide derivative and application thereof, particularly relates to a novel nitrogen heterocyclic ring group substituted amide derivative and a drug composition comprising the compound, and further relates to methods for preparing the compound and the drug composition, and application of the compound and the drug composition to preparation of drugs for treating diseases or symptoms, particularly overactive bladder, excited and mediated by beta 3-adrenergic receptors. The compound and the drug composition can be used for activating the beta 3-adrenergic receptors.