22414-26-2

Basic information

• Product Name: 2-Phenyl-propionyl chloride
• Synonyms: 2-phenylpropenyl chloride;2-phenylpropanoyl chloride
• CAS NO: 22414-26-2
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.62
• Mol File: 22414-26-2.mol
• Article Data: 85

Chemical Properties

• Melting Point: 112-114 °C(Solv: ligroine (8032-32-4); dichloromethane (75-09-2))
• Boiling Point: 98-100 °C(Press: 15 Torr)
• Appearance: /
• Density: 1.139±0.06 g/cm3(Predicted)
• BRN: 1938154
• CAS DataBase Reference: 2-Phenyl-propionyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-propionyl chloride(22414-26-2)
• EPA Substance Registry System: 2-Phenyl-propionyl chloride(22414-26-2)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8 / PGII
• WGK Germany: 3
• Hazardous Substances Data: 22414-26-2(Hazardous Substances Data)

Usage

General Description

2-Phenyl-propionyl chloride, depicted by the molecular formula C9H9ClO, is a chemical compound that belongs to the class of organic compounds known as cinnamic acid derivatives. It is characterized by a cinnamic acid moiety, which is itself derived from phenylalanine. It is commonly used as a reagent in various organic synthesis processes, such as the formation of amides and esters. 2-Phenyl-propionyl chloride is known to be a clear to pale yellow liquid, with a melting point of -75 degrees Celsius and a boiling point of 247 degrees Celsius. It should be handled with care as it can cause burns and other serious health hazards if it comes into contact with skin or eyes. Its use should always be in a controlled environment following safety protocols.

Upstream product

• 1823-91-2 1-phenylethyl cyanide 
• 79-37-8 oxalyl dichloride 
• 492-37-5 hydratropic acid 
• 2901-11-3 ester tertiobutylique de l'acide phenyl-2 propionique 
• 101-41-7 benzeneacetic acid methyl ester 
• 31508-44-8 2-phenylpropionic acid methyl ester 
• 103-82-2 phenylacetic acid 
• 7719-09-7 thionyl chloride 
• 98-86-2 acetophenone 
• 34713-70-7 2-Phenylpropanal 
• 77-83-8 fraeseol 
• 1123-85-9 (RS)-2-phenyl-1-propanol 

Downstream Products

• 55875-34-8 2-phenyl-propionic acid-(N'-methyl-N'-phenyl-hydrazide) 
• 37991-67-6 (2-phenyl-propionyl)-urea 
• 35258-38-9 rac-1-(4-methoxyphenyl)-2-phenylpropan-1-one 
• 7782-24-3 (S)-2-Phenylpropionic acid 
• 7782-26-5 (R)-2-Phenylpropionic acid 
• 119393-03-2 (S)-2-Phenylpropionsaeure-isopropylester 
• 119393-02-1 (R)-2-Phenylpropionsaeure-isopropylester 
• 2901-11-3 ester tertiobutylique de l'acide phenyl-2 propionique 
• 174685-45-1 2-methoxyphenyl 2-phenylpropanoate 
• 55696-39-4 Methyl-γ-phenyl-γ-methylacetoacetat 
• 188396-20-5 ethyl 3-oxo-4-phenylpentanoate 
• 209598-02-7 2-Phenyl-thiopropionic acid S-allyl ester 
• 209598-05-0 2-Phenyl-thiopropionic acid S-(2,2,2-trifluoro-ethyl) ester 
• 100683-61-2 S-phenyl 2-phenylpropylthioester 

Relevant articles and documents

The Structure of Fortesol, a Novel Fused Tricyclic Alcohol Used for Resolution of Phosphinic and Carboxylic Acids

-

Structures and ambident reactivities of azolium enolates

Oxygen versus carbon: Azolium enolates were generated by the reactions of N-heterocyclic carbenes (NHCs) with methyl phenyl ketene and characterized by X-ray crystallography. Kinetic studies show that the enolate oxygen is 20 times more nucleophilic than

Synthesis and in vitro anti-platelet aggregation activities of 2-methoxy-5-arylamido-N-(pyridin-3-yl-methyl)benzamides

In order to discover novel compounds with anti-platelet aggregation activities, a series of novel 2-methoxy-5-arylamido-N-(pyridin-3-ylmethyl)benzamides (1a–n) were synthesized and their anti-platelet aggregation activities were evaluated by the turbidimetric method in response to the following agonists: adenosine diphosphate (ADP) (5 mM/L), arachidonic acid (AA) (20 μM/L), and collagen (1 mg/mL). Those synthesized compounds that have better in vitro activities were subjected to cell toxicity tests via cell counting kit-8 (CCK-8) assay. The biological evaluation revealed that compound 1a (IC50: 0.21 μM/L) exhibited the highest anti-platelet aggregation activities when ADP was selected as an inducer, and compound 1b (IC50: 0.23 μM/L) showed the best activities when AA was selected as inducer, and compound 1m (inhibition rate: 55.06%) had significant anti-platelet aggregation activities when collagen was selected as inducer among all target compounds. Moreover, the effect of cell toxicity exhibited that none of the compounds had obvious cell toxicity against L929 cells. Therefore, 2-methoxy-5-arylamido-N-(pyridin-3-ylmethyl)benzamides have the potential to become a novel kind of anti-platelet drugs and deserve further study.

PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation

A PCl3-mediated conversion of tert-butyl esters into esters and amides in one-pot under air is developed. This novel protocol is highlighted by the synthesis of skeletons of bioactive molecules and gram-scale reactions. Mechanistic studies revealed that this transformation involves the formation of an acid chloride in situ, which is followed by reactions with alcohols or amines to afford the desired products.

COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF

It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators.