2243-83-6 Usage
Description
2-Naphthoyl chloride is an organic compound with the chemical formula C11H7ClO2. It is a white low melting solid, known for its versatile chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
2-Naphthoyl chloride is used as a key intermediate in the synthesis of various pharmaceutical compounds, including anticancer and anti-inflammatory agents. Its unique chemical structure allows for the development of novel therapeutic agents with improved efficacy and reduced side effects.
Used in Chemical Synthesis:
2-Naphthoyl chloride is used as a reagent in the preparation of amide derivatives of the amphetamine enantiomers. This application is crucial for the development of chiral compounds with specific biological activities and potential use in the pharmaceutical industry.
Used in Dye Synthesis:
2-Naphthoyl chloride is used in the synthesis of 7-dimethylamino-2-methyl-3-naphthamido-phenothiazinium salt, a type of phenothiazinium dye. These dyes have various applications, including as pigments, sensors, and in the development of new materials with unique optical properties.
Used in Surface Modification:
2-Naphthoyl chloride is used for the modification of self-assembled monolayers formed on silica surfaces from ((((aminoethyl)amino)-methyl)phenethyl)trimethoxysilane. This application is important in the field of nanotechnology and materials science, as it allows for the creation of functionalized surfaces with tailored properties for various applications, such as sensors, catalysts, and drug delivery systems.
Check Digit Verification of cas no
The CAS Registry Mumber 2243-83-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,4 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2243-83:
(6*2)+(5*2)+(4*4)+(3*3)+(2*8)+(1*3)=66
66 % 10 = 6
So 2243-83-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H7ClO/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H
2243-83-6Relevant articles and documents
One-step Conversion of Amides and Esters to Acid Chlorides with PCl3
Li, Fangshao,Wu, Xiaofang,Guo, Fengzhe,Tang, Zi-Long,Xiao, Jing
supporting information, p. 4314 - 4317 (2021/07/16)
A general and efficient iodine-promoted chlorination of amides and esters with phosphorus trichloride is described. For the first time. Various inactivated amides including secondary and tertiary amides were directly converted to the corresponding acid chlorides in one-step. The substrate scope of methyl esters including aromatic and aliphatic esters was also explored under this system. This method is simple, scalable and wide in scope, which provides an approach to preparation of these acid chlorides.
PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation
Wu, Xiaofang,Zhou, Lei,Li, Fangshao,Xiao, Jing
, p. 491 - 497 (2021/01/20)
A PCl3-mediated conversion of tert-butyl esters into esters and amides in one-pot under air is developed. This novel protocol is highlighted by the synthesis of skeletons of bioactive molecules and gram-scale reactions. Mechanistic studies revealed that this transformation involves the formation of an acid chloride in situ, which is followed by reactions with alcohols or amines to afford the desired products.
A practical chlorination of tert-butyl esters with PCl3 generating acid chlorides
Wu, Xiaofang,Zhou, Lei,Yang, Ruoqi,Guo, Fengzhe,Tang, Zi-Long,Xiao, Jing
, p. 301 - 304 (2020/01/29)
For the first time, using PCl3, a range of tert-butyl esters is chlorinated successfully, allowing access of both aromatic acid chlorides and aliphatic acid chlorides in good yields. The method features simple reaction conditions and wide substrate scope. Various tert-butyl esters including aryl esters, alkenyl esters, and alkyl esters were tolerated well in the reaction. A plausible mechanism is proposed.
