22700-43-2

Basic information

• Product Name: diethyl (2-methoxyphenyl)phosphoramidate
• CAS NO: 22700-43-2
• Molecular Formula: C₁₁H₁₈NO₄P
• Molecular Weight: 259.2387
• Mol File: 22700-43-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 328.3°C at 760 mmHg
• Flash Point: 152.4°C
• Density: 1.182g/cm³
• Vapor Pressure: 0.000191mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: diethyl (2-methoxyphenyl)phosphoramidate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (2-methoxyphenyl)phosphoramidate(22700-43-2)
• EPA Substance Registry System: diethyl (2-methoxyphenyl)phosphoramidate(22700-43-2)

Safety Data

• Hazardous Substances Data: 22700-43-2(Hazardous Substances Data)

Upstream product

• 91-23-6 2-Nitroanisole 
• 122-52-1 triethyl phosphite 
• 23896-88-0 formic acid o-anisidide 
• 762-04-9 phosphonic acid diethyl ester 
• 55860-22-5 2-chloro-N-(2-methoxyphenyl)acetamide 
• 90-04-0 2-methoxy-phenylamine 
• 762-04-9 Diethyl phosphonate 

Downstream Products

• 1266570-35-7 diethyl 2-methoxy-4-(1,3,3-triphenylpropa-1,2-dienyl)phenylphosphoramidate 

Relevant articles and documents

Organophotocatalytic Synthesis of Phosphoramidates

We describe the use of visible light in conjunction with an organic dye for the synthesis of phosphoramidates. Cross dehydrogenative coupling reactions between phosphites and amines are reported using organic dyes and light as catalysts for the first time. It is not only a novel application of organic dyes but also fulfils the requirement of sustainability and green chemistry avoiding the use of chromatographic purification techniques. The product was simply isolated from the reaction mixture via an acid-base work-up procedure, rendering the pure product in good yields.

A New Approach to the Atherton-Todd Reaction

N-Arylphosphoramidates 4 are prepared by reacting formanilides 1 and chloroacetanilides 1' with diethyl phosphite under phase-transfer conditions.