2280037-51-4

Basic information

• Product Name: 1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one
• CAS NO: 2280037-51-4
• Molecular Weight: 297.744
• Mol File: 2280037-51-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 489.0±55.0 °C(Predicted)
• Density: 1.33±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one(2280037-51-4)
• EPA Substance Registry System: 1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one(2280037-51-4)

Safety Data

• Hazardous Substances Data: 2280037-51-4(Hazardous Substances Data)

Usage

General Description

"1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one" is a chemical compound with a complex structure. It contains a biphenyl group attached to a pyrimidinone ring, with an amino group at the 4-position and a chlorine atom at the 5-position. 1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one may have potential biological or pharmaceutical activities due to its structure, and it could be used in the development of new drugs or as a research tool in medicinal chemistry. Further investigation and testing would be needed to determine its specific properties and potential applications.

Upstream product

• 5122-95-2 3-Biphenylboronic acid 
• 2347-43-5 5-chloro-cytosine 

Relevant articles and documents

Cytosine-Based TET Enzyme Inhibitors

DNA methylation is known as the prima donna epigenetic mark for its critical role in regulating local gene transcription. Changes in the landscape of DNA methylation across the genome occur during cellular transition, such as differentiation and altered neuronal plasticity, and become dysregulated in disease states such as cancer. The TET family of enzymes is known to be responsible for catalyzing the reverse process that is DNA demethylation by recognizing 5-methylcytosine and oxidizing the methyl group via an Fe(II)/alpha-ketoglutarate-dependent mechanism. Here, we describe the design, synthesis, and evaluation of novel cytosine-based TET enzyme inhibitors, a class of small molecule probes previously underdeveloped but broadly desired in the field of epigenetics. We identify a promising cytosine-based lead compound, Bobcat339, that has mid-μM inhibitor activity against TET1 and TET2, but does not inhibit the DNA methyltransferase, DNMT3a. In silico modeling of the TET enzyme active site is used to rationalize the activity of Bobcat339 and other cytosine-based inhibitors. These new molecular tools will be useful to the field of epigenetics and serve as a starting point for new therapeutics that target DNA methylation and gene transcription.

CYTOSINE-BASED TET ENZYME INHIBITORS

Provided herein, in some embodiments, are cytosine analogs, compositions comprising cytosine analogs, and methods of use for inhibiting a Ten-eleven translocation (TET) enzyme.