22950-14-7

Basic information

• Product Name: 4-((4-iodophenyl)sulfonyl)morpholine
• Synonyms: 4-((4-iodophenyl)sulfonyl)morpholine
• CAS NO: 22950-14-7
• Molecular Weight: 353.181
• Mol File: 22950-14-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-((4-iodophenyl)sulfonyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((4-iodophenyl)sulfonyl)morpholine(22950-14-7)
• EPA Substance Registry System: 4-((4-iodophenyl)sulfonyl)morpholine(22950-14-7)

Safety Data

• Hazardous Substances Data: 22950-14-7(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 98-61-3 p-Iodobenzenesulfonyl chloride 
• 73852-88-7 2-(4-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 2751-27-1 4-iodobenzenesulfonyl hydrazide 

Downstream Products

• 332024-98-3 1-(4-(morpholinosulfonyl)phenyl)pyrrolidin-2-one 
• 1265145-07-0 di-tert-butyl 1-(4-(morpholinosulfonyl)phenyl)hydrazine-1,2-dicarboxylate 
• 486422-68-8 [(4-N-morpholine-4-sulfonyl)phenyl]boronic acid 

Relevant articles and documents

Photochemical C-H Activation Enables Nickel-Catalyzed Olefin Dicarbofunctionalization

Alkenes, ethers, and alcohols account for a significant percentage of bulk reagents available to the chemistry community. The petrochemical, pharmaceutical, and agrochemical industries each consume gigagrams of these materials as fuels and solvents each year. However, the utilization of such materials as building blocks for the construction of complex small molecules is limited by the necessity of prefunctionalization to achieve chemoselective reactivity. Herein, we report the implementation of efficient, sustainable, diaryl ketone hydrogen-atom transfer (HAT) catalysis to activate native C-H bonds for multicomponent dicarbofunctionalization of alkenes. The ability to forge new carbon-carbon bonds between reagents typically viewed as commodity solvents provides a new, more atom-economic outlook for organic synthesis. Through detailed experimental and computational investigation, the critical effect of hydrogen bonding on the reactivity of this transformation was uncovered.

Electrochemical synthesis of sulfonamides from arenesulfonohydrazides or sodium p-methylbenzenesulfinate and amines

An efficient electrochemical synthesis of sulfonamides (yields 56–98%) from arenesulfonohydrazides or sodium p-methylbenzenesulfinate and amines was performed in an undivided cell with graphite anode and iron cathode in MeCN–H2O medium using halides as redox mediators and supporting electrolytes.

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

Compounds of formula (I) and salts and solvates are provided: formula (I). Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.