22961-45-1

Basic information

• Product Name: 4-(PHENYLAMINO)PYRIDINE
• Synonyms: 4-ANILINOPYRIDINE;4-PYRIDINAMINE, N-PHENYL-;4-(PHENYLAMINO)PYRIDINE;AKOS BC-0724;N-phenylpyridin-4-amine;N-(4-Pyridyl)aniline;N-phenyl-4-pyridinamine;phenyl-(4-pyridyl)amine
• CAS NO: 22961-45-1
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.21
• EINECS: 245-352-8
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines
• Mol File: 22961-45-1.mol
• Article Data: 24

Chemical Properties

• Melting Point: 177 °C
• Boiling Point: 324 °C at 760 mmHg
• Flash Point: 149.8 °C
• Appearance: /
• Density: 1.144 g/cm³
• Vapor Pressure: 0.000252mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 6.90±0.10(Predicted)
• CAS DataBase Reference: 4-(PHENYLAMINO)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PHENYLAMINO)PYRIDINE(22961-45-1)
• EPA Substance Registry System: 4-(PHENYLAMINO)PYRIDINE(22961-45-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 22961-45-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H10N2/c1-2-4-10(5-3-1)13-11-6-8-12-9-7-11/h1-9H,(H,12,13)

Upstream product

• 33399-48-3 4-(phenylthio)pyridine 
• 626-61-9 4-Chloropyridine 
• 64-10-8 phenyl carbamate 
• 504-24-5 4-aminopyridine 
• 945-51-7 1,1'-sulfinylbisbenzene 
• 139-66-2 diphenyl sulfide 
• 620-08-6 4-methoxypyridine 
• 62-53-3 aniline 
• 1120-87-2 4-bromopyridin 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 142-04-1 aniline hydrochloride 
• 22752-98-3 N-Pyrid-4-yl-pyridiniumchlorid-hydrochlorid 
• 5421-92-1 1-(4-pyridyl)pyridinium chloride hydrochloride 
• 3881-38-7 1-(4'-pyridyl)-4-pyridone 

Downstream Products

• 73333-84-3 N-Phenyl-N-(4-pyridinyl)benzamide 
• 261-90-5 10H-pyrido<3,4-b><1,4>benzothiazine 
• 172780-12-0 1-[4-(4-pyridylamino)phenyl]-2-chloropropanone 

Relevant articles and documents

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Anticancer-Active N-Heteroaryl Amines Syntheses: Nucleophilic Amination of N-Heteroaryl Alkyl Ethers with Amines

A mild amination protocol of N-heteroaryl alkyl ethers with various amines is described. This transformation is achieved by utilizing simple and readily available base as promoter via C-O bond cleavage, offering a new amination strategy to access several anticancer-active compounds. This work is highlighted by the excellent functional group compatibility, scalability, wide substrate scope, and easy derivatization of a variety of drugs.

Copper-Catalyzed NaBAr 4-Based N-Arylation of Amines

Using NaBAr 4 as an arylating agent, the formation of carbon-heteroatom bonds by a Cham-Lam cross-coupling reaction in the presence of catalytic copper(II) acetate monohydrate in acetonitrile at room temperature under air is described. The investigation of reaction scope suggests that several aliphatic and aromatic amines are compatible. In particular, the reaction of alkylamine and NaBAr 4 proceeds smoothly to offer the corresponding products in good to excellent yields.