23001-29-8

Basic information

• Product Name: 1',3',3'-TRIMETHYL-6-HYDROXYSPIRO(2H-1-BENZOPYRAN-2,2'-INDOLINE)
• Synonyms: 1',3',3'-TRIMETHYL-6-HYDROXYSPIRO(2H-1-BENZOPYRAN-2,2'-INDOLINE);1’,3’-dihydro-1’,3’,3’-trimethyl-spiro[2h-1-benzopyran-2’-[2h]indol]-6-ol;1′,3′,3′-Trimethyl-6-hydroxyspiro (2H-1-benzopyran-2,2′-indoline), GC 99%;1,3,3-Trimethyl-6'-hydroxyspiro[indoline-2,2'-[2H][1]benzopyran];1,3,3-Trimethylspiro[1H-indole-2(3H),2'-[2H-1]benzopyran]-6'-ol;1',3',3'-Trimethylspiro[2H-1-benzopyran-2,2'-[1H]-indole]-6-ol;1',3'-Dihydro-1',3',3'-trimethylspiro[2H-1-benzopyran-2,2'-[2H]indol]-6-ol;1',3',3'-Trimethyl-6-hydroxyspiro(2H-1-benzopyran-2,2'-indoline),99%
• CAS NO: 23001-29-8
• Molecular Formula: C₁₉H₁₉NO₂
• Molecular Weight: 293.36
• Mol File: 23001-29-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 435.21°C (rough estimate)
• Flash Point: 237.8°C
• Appearance: Light brown to purple/Powder
• Density: 1.1349 (rough estimate)
• Refractive Index: 1.5000 (estimate)
• PKA: 9.95±0.40(Predicted)
• CAS DataBase Reference: 1',3',3'-TRIMETHYL-6-HYDROXYSPIRO(2H-1-BENZOPYRAN-2,2'-INDOLINE)(CAS DataBase Reference)
• NIST Chemistry Reference: 1',3',3'-TRIMETHYL-6-HYDROXYSPIRO(2H-1-BENZOPYRAN-2,2'-INDOLINE)(23001-29-8)
• EPA Substance Registry System: 1',3',3'-TRIMETHYL-6-HYDROXYSPIRO(2H-1-BENZOPYRAN-2,2'-INDOLINE)(23001-29-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 24/25
• Hazardous Substances Data: 23001-29-8(Hazardous Substances Data)

Usage

Chemical Properties

light brown to purple powder

Upstream product

• 118-12-7 1,3,3-Trimethyl-2-methyleneindoline 
• 1194-98-5 2,5-Dihydroxybenzaldehyde 

Downstream Products

• 199185-75-6 C₂₆H₂₅NO₂ 
• 20200-73-1 6-methoxy-1',3',3'-trimethyl-spiro[chromene-2,2'-indoline] 
• 287398-52-1 C₂₁H₂₁NO₃ 
• 724460-11-1 1',3',3'-trimethyl-6-acryloyloxyspiro[2H-1-benzopyran-2,2'-indoline] 
• 919091-73-9 [1,3,3-trimethyl-spiro-(2H-1-benzopyran-2,2'-indoline)-6-oxyethyl]-3,4,5-tris(n-octadecyloxy)benzoate 
• 56979-56-7 5-benzyloxy-2-hydroxybenzaldehyde 
• 64418-88-8 2-hydroxy-5-acetyloxybenzaldehyde 
• 1450712-98-7 6-((1',3',3'-trimethylspiro[chromene-2,2'-indolin]-6-yl)oxy)hexyl acrylate 
• 1489115-54-9 6-(tert-butyldimethylsilyloxy)-1′,3′,3′-trimethylspiro [chromene-2,2′-indoline] 
• 158034-75-4 1',3',3'-trimethyl-6-methacryloyloxyspiro[2H-1-benzopyran-2,2'-indoline] 
• 1194-98-5 2,5-Dihydroxybenzaldehyde 

Relevant articles and documents

Synthesis and characterization of new liquid crystals containing a non-activated indolinobenzospiropyranyl group. Part 4*[1]

A series of new liquid crystalline compounds, 1′,3′,3′- Trimethylspiro[2H-1-benzopyran-2,2′-indolin/-6-yl 4-(4′- alkoxyphenylazo)benzoate, SP-APAB 1a ～ 1f, has been synthesized. Their liquid crystallines were subjected to thermal analysis on a differential scanning calorimeter (DSC), to texture of phases on a polarizing microscope and to phase transition on an X-ray diffraction mid electro-optical measurement. Most of compounds examined exhibit monotropic nematic and SmA liquid crystal phases on cooling from isotropic liquid. Suprisingly, SP-APAB 1c is shown to exhibit monotropic SmC phase in addition. X-ray diffraction study of the layer spacing confirmed that there was a layer spacing in the range of two theta from 2.25 to 2.45 A on the temperature near the phase transition from, SmA to SmC.

Photoswitchable hydrogel surface topographies by polymerisation-induced diffusion

Herein, we describe the preparation of patterned photoresponsive hydrogels by using a facile method. This polymer-network hydrogel coating consists of N-isopropylacrylamide (NIPAAM), cross-linking agent tripropylene glycol diacrylate (TPGDA), and a new photochromic spiropyran monoacrylate. In a pre-study, a linear NIPAAM copolymer (without TPGDA) that contained the spiropyran dye was synthesised, which showed relatively fast photoswitching behaviour. Subsequently, the photopolymerisation of a similar monomer mixture that included TPGDA afforded freestanding hydrogel polymer networks. The light-induced isomerisation of protonated merocyanine into neutral spiropyran under slightly acidic conditions resulted in macroscopic changes in the hydrophilicity of the entire polymer film, that is, shrinkage of the hydrogel. The degree of shrinkage could be controlled by changing the chemical composition of the acrylate mixture. After these pre-studies, a hydrogel film with spatially modulated cross-link density was fabricated through polymerisation-induced diffusion, by using a patterned photomask. The resulting smooth patterned hydrogel coating swelled in slightly acidic media and the swelling was higher in the regions with lower cross-linking densities, thus yielding a corrugated surface. Upon exposure to visible light, the surface topography flattened again, thus showing that a hydrogel coating could be created, the topography of which could be controlled by light irradiation.

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS FOR MODULATING TRPV1

Provided are chemical entities chosen from compounds of Formula (I) and pharmaceutically or cosmetically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof. The chemical entities modulate TRPV1 and are useful in the treatment of at least one disease or disorder modulated by TRPV1 activity.