2305-13-7Relevant articles and documents
The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection
Choi, Seul-Ki,Mun, Gil-Im,Choi, Eun,Kim, Seo-Young,Kwon, Youngjoo,Na, Younghwa,Lee, Yun-Sil
, p. 2379 - 2383 (2017)
Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.
-
Granath,Schuerch
, p. 707,709 (1953)
-
Controlled lignosulfonate depolymerization: Via solvothermal fragmentation coupled with catalytic hydrogenolysis/hydrogenation in a continuous flow reactor
Al-Naji, Majd,Antonietti, Markus,Brandi, Francesco
supporting information, p. 9894 - 9905 (2021/12/24)
Sodium lignosulfonate (LS) was valorized to low molecular weight (Mw) fractions by combining solvothermal (SF) and catalytic hydrogenolysis/hydrogenation fragmentation (SHF) in a continuous flow system. This was achieved in either alcohol/H2O (EtOH/H2O or MeOH/H2O) or H2O as a solvent and Ni on nitrogen-doped carbon as a catalyst. The tunability according to the temperature of both SF and catalytic SHF of LS has been separately investigated at 150 °C, 200 °C, and 250 °C. In SF, the minimal Mw was 2994 g mol-1 at 250 °C with a dispersity (?) of 5.3 using MeOH/H2O. In catalytic SHF using MeOH/H2O, extremely low Mw was found (433 mg gLS-1) with a ? of 1.2 combined with 34 mg gLS-1. The monomer yield was improved to 42 mg gLS-1 using dual catalytic beds. These results provide direct evidence that lignin is an unstable polymer at elevated temperatures and could be efficiently deconstructed under hydrothermal conditions with and without a catalyst. This journal is
METHOD OF FORMING MONOMERS AND FURFURAL FROM LIGNOCELLULOSE
-
Page/Page column 19; 21; 22, (2020/06/05)
The present disclosure relates to a method of producing monophenolicmonomers and furfural from lignocellulosic biomass beating the biomass in a solvent together with a zeolite based catalyst.