2305-26-2Relevant articles and documents
Spontaneous formation and stabilization of radicals during the cocrystallization of alicyclic and peroxyalicyclic dicarboxylic acids
Starostin, Evgenii K.,Lalov, Andrei V.,Ignatenko, Anatolii V.,Nikishin, Gennady I.
, p. 123 - 125 (2008)
The cocrystallization of di(cis-2-carboxycyclohexylcarbonyl) peroxide and cyclohexane-1,2-dicarboxylic acid from aqueous solution affords stable 1-carboxycyclohexyl radicals, which were identified by EPR spectroscopy.
Production synthesis method of cis-1, 2, 3, 6-tetrahydrophthalimide
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Paragraph 0024-0026, (2020/08/06)
The invention provides a production synthesis method of cis-1, 2, 3, 6-tetrahydrophthalimide. The method comprises the following steps: S1, heating and melting solid 1, 2, 3, 6-tetrahydrophthalic anhydride, stirring, raising the temperature, stopping heating, adding urea at a specific constant speed, preserving heat for 3-5 minutes, then adding urea at the same constant speed again at 130-135 DEGC, preserving heat for 2-2.5 hours, and stopping reaction after the reaction is detected to be complete, and S2, heating and dissolving the product obtained in the step S1 with deionized water, cooling, standing to separate out crystals, carrying out suction filtration, washing with ice water, and drying to obtain white cis-1, 2, 3, 6-tetrahydrophthalimide. According to the method, urea is continuously added in batches at a specific temperature, so that the utilization rate of raw materials is effectively increased, side reactions are reduced, the product quality is improved, the conditions inthe synthesis process are mild and controllable, and environmental protection and actual industrial application are facilitated.
Truncated borrelidin analogues: Synthesis by sequential cross metathesis/olefination for the southern fragment and biological evaluation
Gündemir-Durmaz, Tülay,Schmid, Fabian,El Baz, Yana,H?usser, Annette,Schneider, Carmen,Bilitewski, Ursula,Rauhut, Guntram,Garnier, Delphine,Baro, Angelika,Laschat, Sabine
supporting information, p. 8261 - 8269 (2016/09/09)
The construction of novel borrelidin analogues is reported in which the northern fragment is truncated to a simple hydroxyundecanecarboxylate and the original cyclopentanecarboxylic acid in the southern fragment is replaced with different six-membered rings. The required precursors were prepared by cross metathesis of the appropriate carbocycle-based homoallylic alcohol with crotonaldehyde followed by HWE olefination of the resulting enal with bromocyanophosphonate. The key aldehyde for intramolecular cross coupling was accessible by oxidation of the hydroxy group of the linked undecanecarboxylate unit. Grignard mediated macrocyclization finally yielded the borrelidin related products. The investigation is complemented by SAR studies and quantum-chemical calculations.
