23092-17-3

Basic information

• Product Name: HALAZEPAM CIV (200 MG) (AS)
• Synonyms: HALAZEPAM CIV (200 MG) (AS);2,2-trifluoroethyl)-2h-1,4-benzodiazepin-7-chloro-3-dihydro-5-phenyl-1-(2;2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-;2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-1-(2,2,2-trifluoroethyl)-;2h-1,4-benzodiazepin-2-one,1,3-dihydro-7-chloro-5-phenyl-1-(2,2,2-trifluoroeth;7-Chloro-1,3-dihydro-5-phenyl-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepin-2-one;7-Chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;Halezepam
• CAS NO: 23092-17-3
• Molecular Formula: C₁₇H₁₂ClF₃N₂O
• Molecular Weight: 352.7381896
• EINECS: 245-425-4
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 23092-17-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 164-166°
• Boiling Point: 487.8°Cat760mmHg
• Flash Point: 248.8°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 1.15E-09mmHg at 25°C
• Refractive Index: 1.583
• PKA: 2.61±0.20(Predicted)
• CAS DataBase Reference: HALAZEPAM CIV (200 MG) (AS)(CAS DataBase Reference)
• NIST Chemistry Reference: HALAZEPAM CIV (200 MG) (AS)(23092-17-3)
• EPA Substance Registry System: HALAZEPAM CIV (200 MG) (AS)(23092-17-3)

Safety Data

• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 23092-17-3(Hazardous Substances Data)

Usage

Description

HALAZEPAM CIV (200 MG) (AS) is a benzodiazepine derivative that exhibits anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. It serves as a precursor to Desmethyldiazepam (D291595) and is considered equal to or more effective than Diazepam (D416855) with a lower frequency of side effects. As a controlled substance, it is marketed under the brand name Paxipam by Schering.

Uses

Used in Pharmaceutical Industry:
HALAZEPAM CIV (200 MG) (AS) is used as an anxiolytic agent for treating anxiety disorders, providing relief from symptoms associated with anxiety and stress.
HALAZEPAM CIV (200 MG) (AS) is used as an anticonvulsant medication for managing seizures and other convulsive disorders, helping to prevent and control seizure episodes.
HALAZEPAM CIV (200 MG) (AS) is used as a sedative for inducing sleep and promoting relaxation in patients with insomnia or other sleep disorders.
HALAZEPAM CIV (200 MG) (AS) is used as a skeletal muscle relaxant to alleviate muscle spasms, pain, and stiffness, improving mobility and comfort in patients with muscle-related conditions.

InChI:InChI=1/C17H12ClF3N2O/c18-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)22-9-15(24)23(14)10-17(19,20)21/h1-8H,9-10H2

Upstream product

• 22753-80-6 5-chloro-2-[(2,2,2-trifluoroethyl)amino]benzophenone 

Relevant articles and documents

Process for the preparation of 1,4-benzo-diazepines and 1,4-benzodiazepinones

This invention relates to an improved process for the preparation of 1,3-dihydro-2H-1,4-benzodiazepin-2-ones and 2,3-dihydro-1H-1,4-benzodiazepines by the condensation of a 2-(2-haloacylamido)-benzophenone or a 2-(2-haloethylamino)-benzophenone, respectively, in the presence of hexamethylenetetramine, a water miscible alcohol containing 5 to 50 volume percent water, and an ammonium salt.

1-POLYHALOGENOALKYL-2-OXO-1,3-DIHYDRO-2H-1,4-BENZODIAZEPINES

This invention relates to 2-oxo-1,3-dihydro-2H-1,4-dibenziodiazepines, and the 4-N-oxides thereof, having a polyfluoroalkyl radical attached at the 1-position thereof, to their use as muscle relaxants, as sedatives, an anticonvulsants, and as anti-anxiety agents and to the intermediates useful in the preparation thereof. The compounds may be prepared by N-polyfluoroalkylating the appropriately substituted 2-oxo-1,3-dihydro-2H-1,4-benzodiazepines. Alternate methods for the synthesis of the compounds of this invention are also described