2343-89-7Relevant articles and documents
SYNTHESIS OF METHYL 2-FLUOROACRYLATE
-
Paragraph 00119, (2021/10/02)
Methods for the synthesis of methyl 2-fluoroacrylate (MFA) are provided. The methods include use of various hydrofluorination agents using a variety of starting materials and reaction schemes. The methyl 2-fluoroacrylate prepared by the methods described herein can further be used to prepare patiromer calcium sorbitex.
ONE STEP SYNTHESIS FOR ALKYL 2-FLUOROACRYLATES
-
Paragraph 0073-0078, (2021/05/21)
A process is provided that results in an alkyl haloacrylate that is produced by reaction of a dialkyl or diaryl halomalonate with an aldehyde, preferably formalin or paraformaldehyde, and a base catalyst to produce an intermediate that is not isolated and is heated to produce the alkyl haloacrylate. This synthesis can be one pot, meaning it reacts in the same vessel and/or reaction mixture and does not require isolation of the intermediate, and provides an improved yield. In particular, a process is provided that results in an alkyl 2-fluoroacrylate.
Preparation method of methyl 2-fluoroacrylate
-
Paragraph 0061; 0063-0068; 0070-0075; 0077-0081, (2020/05/30)
A preparation method of methyl 2-fluoroacrylate comprises the following steps: adding a solvent into a reaction kettle, dissolving methyl acrylate into the solvent, emptying, controlling the reactiontemperature in the reaction kettle, introducing fluorine gas, raising the temperature in the reaction kettle, removing HF under an alkaline condition to obtain a methyl 2-fluoroacrylate mother solution, and standing the mother solution; raising the temperature of the 2-fluoromethyl acrylate mother solution, and then carrying out hot filtration on the 2-fluoromethyl acrylate mother solution to obtain a 2-fluoromethyl acrylate filtrate; recrystallizing the 2-fluoromethyl acrylate filtrate to obtain crude 2-fluoromethyl acrylate; and rectifying the crude 2-fluoromethyl acrylate, and collecting the obtained fraction to obtain pure 2-fluoromethyl acrylate. The method has low requirements on equipment, can effectively inhibit the activity of F2 and reduce the generation of byproducts, can improve the yield and purity of the product, and can effectively remove the reaction raw materials and the solvent to obtain the high-purity methyl 2-fluoroacrylate.