23452-05-3 Usage
Description
Alternariol monomethyl ether (AME) is a mycotoxin produced by the fungus Alternaria, which is a major plant pathogen found in a wide variety of fruits and cereal products. It is also a natural mycotoxin isolated from the fermentation broth of Trichoderma sp. Jing-8, exhibiting phytotoxic, antibacterial, and antioxidant activities. Additionally, AME is derived from 3,5-Dimethoxyiodobenzene (D460640), an intermediate for the synthesis of glucuronide conjugates of trans-Resveratrol.
Uses
Used in Agriculture:
Alternariol monomethyl ether is used as a phytotoxic agent for its ability to protect crops from various plant pathogens, enhancing crop yield and quality.
Used in Antibacterial Applications:
AME is used as an antibacterial agent due to its natural ability to inhibit the growth of certain bacteria, contributing to the development of new antimicrobial solutions.
Used in Antioxidant Applications:
Alternariol monomethyl ether is used as an antioxidant agent for its capacity to neutralize harmful free radicals, potentially offering benefits in the food industry and pharmaceuticals for preserving the quality and shelf life of products.
Used in Chemical Synthesis:
AME is used as an intermediate in the synthesis of glucuronide conjugates of trans-Resveratrol, which has potential applications in the pharmaceutical and nutraceutical industries for its various health-promoting properties.
Used in Mycotoxin Research:
Alternariol monomethyl ether is used as a subject of study in the field of mycotoxin research to better understand its effects on human and animal health, as well as to develop strategies for its detection and mitigation in the food supply.
Check Digit Verification of cas no
The CAS Registry Mumber 23452-05-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,4,5 and 2 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 23452-05:
(7*2)+(6*3)+(5*4)+(4*5)+(3*2)+(2*0)+(1*5)=83
83 % 10 = 3
So 23452-05-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H12O5/c1-7-3-8(16)4-12-13(7)10-5-9(19-2)6-11(17)14(10)15(18)20-12/h3-6,16-17H,1-2H3
23452-05-3Relevant articles and documents
PARTIAL PURIFICATION AND SOME PROPERTIES OF AN ALTERNARIOL-O-METHYLTRANSFERASE FROM ALTERNARIA TENUIS
Stinson, E. E.,Moreau, R. A.
, p. 2721 - 2724 (2007/10/02)
Key Word Index - Alternaria tenuis; Hyphomycetes; alternariol; coumarin; alternariol-O-methyltransferase; mycotoxin metabolism.A new methyltransferase, alternariol-O-methyltransferase (AOH-MT) was identified in the mould Alternaria tenuis NRRL6434.This enzyme catalyses the methylation of alternariol (AOH), a phenolic mycotoxin, to produce alternariol monomethyl ether (AME).The methyl donor is S-adenosyl-L-methionine (SAM).This activity is cytosolic and is not associated with membrane or particulate material.A 15.5-fold purification was achieved.Experimentation with the partially purified enzyme revealed that AOH-MT is not associated with AOH-synthetase activity.Enzymic activity was associated with a single peak of activity with Mr ca 110 000.This enzyme exhibits optimum activity at pH 8.0.Magnesium stimulates AOH-MT activity.Despite the apparent structural similarity of the substrate to substituted coumarins and cinnamic acids, the cell-free extract displayed no methyltransferase activity towards these compounds.The enzyme has an apparent Km of 38 μM for AOH and an apparent Km of 31 μM for SAM.
