23462-25-1 Usage
Description
Phenazine-1,6-dicarboxylate is a member of the phenazine class, characterized by carboxy substituents at positions 1 and 6. It is a natural product derived from Streptomyces species, which are a group of Gram-positive bacteria known for producing various bioactive compounds.
Uses
Used in Pharmaceutical Industry:
Phenazine-1,6-dicarboxylate is used as a pharmaceutical compound for its potential therapeutic applications. It is being investigated for its bioactive properties, which may include antimicrobial, anti-inflammatory, and anticancer activities. The compound's unique structure allows it to interact with various biological targets, making it a promising candidate for drug development.
Used in Research Applications:
Phenazine-1,6-dicarboxylate is also used as a research tool in the field of microbiology and biochemistry. It serves as a model compound to study the biosynthesis, metabolism, and ecological roles of phenazines in Streptomyces species. Additionally, it can be used to investigate the mechanisms of action of various enzymes and proteins that interact with phenazines.
Used in Environmental Applications:
Phenazine-1,6-dicarboxylate may have potential applications in environmental biotechnology, such as bioremediation and biocontrol. Its antimicrobial properties could be harnessed to control the growth of harmful microorganisms in various settings, including agriculture, water treatment, and industrial processes. Further research is needed to explore these applications and optimize the use of phenazine-1,6-dicarboxylate in environmental contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 23462-25-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,4,6 and 2 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 23462-25:
(7*2)+(6*3)+(5*4)+(4*6)+(3*2)+(2*2)+(1*5)=91
91 % 10 = 1
So 23462-25-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H8N2O4/c17-13(18)7-3-1-5-9-11(7)16-10-6-2-4-8(14(19)20)12(10)15-9/h1-6H,(H,17,18)(H,19,20)
23462-25-1Relevant articles and documents
Dual phenazine gene clusters enable diversification during biosynthesis
Shi, Yi-Ming,Brachmann, Alexander O.,Westphalen, Margaretha A.,Neubacher, Nick,Tobias, Nicholas J.,Bode, Helge B.
, p. 331 - 339 (2019/04/17)
Biosynthetic gene clusters (BGCs) bridging genotype and phenotype continuously evolve through gene mutations and recombinations to generate chemical diversity. Phenazine BGCs are widespread in bacteria, and the biosynthetic mechanisms of the formation of the phenazine structural core have been illuminated in the last decade. However, little is known about the complex phenazine core-modification machinery. Here, we report the diversity-oriented modifications of the phenazine core through two distinct BGCs in the entomopathogenic bacterium Xenorhabdus szentirmaii, which lives in symbiosis with nematodes. A previously unidentified aldehyde intermediate, which can be modified by multiple enzymatic and non-enzymatic reactions, is a common intermediate bridging the pathways encoded by these BGCs. Evaluation of the antibiotic activity of the resulting phenazine derivatives suggests a highly effective strategy to convert Gram-positive specific phenazines into broad-spectrum antibiotics, which might help the bacteria–nematode complex to maintain its special environmental niche.
