2379-55-7Relevant articles and documents
Optimisation of conoidin A, a peroxiredoxin inhibitor
Liu, Gu,Botting, Catherine H.,Evans, Kathryn M.,Walton, Jeffrey A. G.,Xu, Guogang,Slawin, Alexandra M. Z.,Westwood, Nicholas J.
, p. 41 - 45 (2010)
Lead optimisation: Interest in the inhibition of peroxiredoxin has been revitalised by their recently identified role in signalling cascades. Here, the synthesis and analysis of novel analogues of the peroxiredoxin inhibitor conoidin A is described. Computational methods are used to rationalise the generated SAR data. These studies lead to a proposed binding mode for this class of compounds that will aid the design of second generation inhibitors. (Figure Presented)
Isolation and determination of α-dicarbonyl compounds by RP-HPLC-DAD in green and roasted coffee
Daglia, Maria,Papetti, Adele,Aceti, Camilla,Sordelli, Barbara,Spini, Valentina,Gazzani, Gabriella
, p. 8877 - 8882 (2007)
Glyoxal, methylglyoxal, and diacetyl formed as Maillard reaction products in heat-treated food were determined in coffee extracts (coffee brews) obtained from green beans and beans with different degrees of roast. The compounds have been reported to be mutagenic in vitro and genotoxic in experimental animals in a number of papers. More recently, α-dicarbonyl compounds have been implicated in the glycation process. Our data show that small amounts of glyoxal and methylglyoxal occur naturally in green coffee beans. Their concentrations increase in the early phases of the roasting process and then decline. Conversely, diacetyl is not found in green beans and forms later in the roasting process. Therefore, light and medium roasted coffees had the highest glyoxal and methylglyoxal content, whereas dark roasted coffee contained smaller amounts of glyoxal, methylglyoxal, and diacetyl. For the determination of coffee α-dicarbonyl compounds, a reversed-phase high performance liquid chromatography with a diode array detector (RP-HPLC-DAD) method was devised that involved the elimination of interfering compounds, such as chlorogenic acids, by solid phase extraction (SPE) and their derivatization with 1,2-diaminobenzene to give quinoxaline derivatives. Checks of SPE and derivatization conditions to verify recovery and yield, respectively, resulted in rates of 100%. The results of the validation procedure showed that the proposed method is selective, precise, accurate, and sensitive.
POTENTIAL ALARM PHEROMONES FROM THE MEDITERRANEAN OPISTHOBRANCH SCAPHANDER LIGNARIUS
Cimino, G.,Spinella, A.,Sodano, G.
, p. 5003 - 5004 (1989)
Two new ω-phenyl conjugated trienones, lignarenone-A (2) and lignarenone-B (3), are the main metabolites isolated from the dorsum acetone extract of Scaphander lignarius.Their structures, closely related to 3-methyl navenone-B (1) a minor component of the alarm pheromone mixture of the opisthobranch Navanax inermis, were characterized by spectral methods.
-
Wasa,Musha
, p. 1617,1618 (1967)
-
In water organic synthesis: Introducing itaconic acid as a recyclable acidic promoter for efficient and scalable synthesis of quinoxaline derivatives at room temperature
Tamuli, Kashyap J.,Nath, Shyamalendu,Bordoloi, Manobjyoti
supporting information, p. 983 - 1002 (2021/02/27)
Substituted quinoxaline derivatives are traditionally synthesized by co-condensation of various starting materials. Herein, we describe a novel environmentally benign in water synthetic route for the synthesis of structurally and electronically diverse ninety quinoxalines with readily available substituted o-phenylenediamine and 1,2-diketones using cheap and biodegradable itaconic acid as a mild acid promotor in 1 hours. The reaction is performed at room temperature, which proceeds through cyclo-condensation reaction followed by obtaining the aforesaid nitrogen-containing heterocyclic adducts without performing the column chromatography up to 96% total yields. The simplicity, high efficiency, and reusable of the catalyst merits this reaction condition as “green synthesis” which enables it to be useful in synthetic transformations upto gram scale level.
NaOH-Mediated Direct Synthesis of Quinoxalines from o-Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy
Wang, Yan-Bing,Shi, Linlin,Zhang, Xiaojie,Fu, Lian-Rong,Hu, Weinan,Zhang, Wenjing,Zhu, Xinju,Hao, Xin-Qi,Song, Mao-Ping
supporting information, p. 947 - 958 (2021/01/14)
A NaOH-mediated sustainable synthesis of functionalized quinoxalines is disclosed via redox condensation of o-nitroamines with diols and α-hydroxy ketones. Under optimized conditions, various o-nitroamines and alcohols are well tolerated to generate the desired products in 44-99% yields without transition metals and external redox additives.
Hydrogen Auto-transfer Synthesis of Quinoxalines from o-Nitroanilines and Biomass-based Diols Catalyzed by MOF-derived N,P Co-doped Cobalt Catalysts
Sun, Kangkang,Li, Dandan,Lu, Guo-Ping,Cai, Chun
, p. 373 - 381 (2020/12/09)
A Co-based heterogeneous catalyst supported on N,P co-doped porous carbon (Co@NCP) is prepared via a facile in-situ doping-carbonization method. The Co@NCP composite features a large surface area, high pore volume, high-density and strong basic sites. Furthermore, doping of P atoms can regulate the electronic density of Co. Therefore, Co@NCP exhibits good performance for the synthesis of quinoxalines from o-nitroanilines and biomass-derived diols under alkali-free conditions.