23833-97-8Relevant articles and documents
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Heindel,Kennewell
, p. 166,167 (1970)
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Cobalt(III)- and Rhodium(III)-Catalyzed C-H Amidation and Synthesis of 4-Quinolones: C-H Activation Assisted by Weakly Coordinating and Functionalizable Enaminone
Wang, Fen,Jin, Liang,Kong, Lingheng,Li, Xingwei
supporting information, p. 1812 - 1815 (2017/04/11)
Cobalt(III) and rhodium(III) catalysts exhibited complementary scope in C-H amidation of aryl enaminones. The amidation reactions proceeded with broad scope under the assistance of a weakly coordinating and bifunctional enaminone directing group. The electrophilicity of the enaminone group can be further utilized in subsequent hydrolysis-cyclization reactions to afford NH 4-quinolones in telescoping reactions.
Co(III)-Catalyzed Enaminone-Directed C-H Amidation for Quinolone Synthesis
Shi, Pengfei,Wang, Lili,Chen, Kehao,Wang, Jie,Zhu, Jin
, p. 2418 - 2421 (2017/05/12)
We report herein the development of a Co(III)-catalyzed enaminone-directed C-H amidation method for synthetic access to quinolones, an important heterocyclic scaffold for diverse pharmaceutically active structures. The C-H coupling with dioxazolones and subsequent deacylation of an installed amide group allow consecutive C-N coupling generation of quinolones with wide-ranging compatible substituent patterns.