2389-49-3 Usage
Description
Methyl N6-[(1,1-dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysinate, also known as Z-Lys(Boc)-OMe, is a chemical compound derived from L-lysine, an essential amino acid. It is characterized by the presence of a carboxylic acid group, an amino group, and a methyl ester group. methyl N6-[(1,1-dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysinate is modified with a 1,1-dimethylethoxycarbonyl group at the N6 position and a phenylmethoxycarbonyl group at the N2 position, which contribute to its unique properties and potential applications.
Uses
Used in Pharmaceutical Industry:
Z-Lys(Boc)-OMe is used as a building block in the synthesis of peptide-based drugs and drug delivery systems. Its unique structure allows for the development of stimuli-responsive cationic nanoparticles, which can be triggered to release their cargo in response to specific stimuli, such as pH changes or enzymatic activity. This property makes it a promising candidate for targeted drug delivery and controlled release applications.
Used in Chemical Synthesis:
Z-Lys(Boc)-OMe is used as an intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its versatility as a building block allows for the creation of a wide range of products with diverse applications.
Used in Research and Development:
Z-Lys(Boc)-OMe is utilized in research settings to study the properties and behavior of amino acids and their derivatives. It can be used to investigate the effects of different modifications on the chemical and physical properties of L-lysine, as well as to explore the potential applications of these modified compounds in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 2389-49-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,8 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2389-49:
(6*2)+(5*3)+(4*8)+(3*9)+(2*4)+(1*9)=103
103 % 10 = 3
So 2389-49-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H30N2O6/c1-20(2,3)28-18(24)21-13-9-8-12-16(17(23)26-4)22-19(25)27-14-15-10-6-5-7-11-15/h5-7,10-11,16H,8-9,12-14H2,1-4H3,(H,21,24)(H,22,25)
2389-49-3Relevant articles and documents
Serine- and threonine-derived diamine equivalents for site-specific incorporation of platinum centers in peptides, and the anticancer potential of these conjugates
Kumbhakonam, Sateeshkumar,Vellaisamy, Kasipandi,Saroj, Soumya,Venkatesan, Nalini,Karunagaran,Manheri, Muraleedharan Kannoth
, p. 2450 - 2458 (2018/02/19)
A modular strategy that allows introduction of one or more reactive platinum units at chosen locations along a peptide sequence is presented. This makes use of diazides generated from serine and threonine as diamine equivalents which can be conjugated to the peptide under standard coupling conditions. Reduction of these diazides using Pd/C and H2 followed by platination affords the final products in good yields. Following this, we prepared a new class of peptide-platinum conjugates and carried out preliminary cytotoxicity evaluation and DNA interaction studies. Inclusion of lysine residues in the sequence was found to improve DNA interaction and anticancer activities compared to analogous conjugates with hydrophobic side chains.
Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists
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Paragraph 0412; 0432, (2014/09/03)
A conjugated compound of Formula I: Q-Z—R4 wherein Q is a TLR7 and/or TLR8 agonist and Z—R4 is a TLR2 agonist, the conjugated compound being chosen among compounds of Formula II:
Cobalt (III) complexes as novel matrix metalloproteinase-9 inhibitors
Lee, Jiyoun
, p. 2762 - 2764 (2012/11/07)
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