24059-72-1

Basic information

• Product Name: 1-(M-Tolyl)pyrrolidin-2-one
• Synonyms: 1-(M-Tolyl)pyrrolidin-2-one;AH-214/02403035;NSC231482;ST065719;ZINC00406415
• CAS NO: 24059-72-1
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol File: 24059-72-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 386.9°Cat760mmHg
• Flash Point: 191.1°C
• Appearance: /
• Density: 1.117g/cm³
• Vapor Pressure: 3.43E-06mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 1-(M-Tolyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(M-Tolyl)pyrrolidin-2-one(24059-72-1)
• EPA Substance Registry System: 1-(M-Tolyl)pyrrolidin-2-one(24059-72-1)

Safety Data

• Hazardous Substances Data: 24059-72-1(Hazardous Substances Data)

Usage

General Description

1-(M-Tolyl)pyrrolidin-2-one, also known as N-methyl-3,4-dimethylphenyl-2-pyrrolidinone, is a chemical compound with the molecular formula C12H15NO. It is a white solid at room temperature and is used in the synthesis of various pharmaceutical drugs and organic compounds. This chemical is a pyrrolidinone derivative and is commonly used as an intermediate in the production of medicines, pesticides, and other organic compounds. It has a wide range of applications in the pharmaceutical and chemical industries due to its reactivity and versatility as a building block in organic synthesis.

InChI:InChI=1/C11H13NO/c1-9-4-2-5-10(8-9)12-7-3-6-11(12)13/h2,4-5,8H,3,6-7H2,1H3

Upstream product

• 73863-44-2 N-(4-chlorobutyryl)-m-toluidine 
• 110-63-4 Butane-1,4-diol 
• 108-44-1 1-amino-3-methylbenzene 
• 71982-24-6 N-(3-methylphenyl)piperidine 
• 591-17-3 meta-bromotoluene 
• 616-45-5 2-pyrrolidinon 
• 625-95-6 3-Iodotoluene 
• 96-48-0 4-butanolide 

Downstream Products

• 13691-27-5 1-(4-amino-3-methyl-phenyl)-pyrrolidin-2-one 
• 179171-66-5 N-(4-Oxo-hexyl)-N-m-tolyl-oxalamic acid ethyl ester 
• 162142-28-1 3-hydroxy-2-oxo-4-propionyl-1-(3-methylphenyl)-1,2,5,6-tetrahydropyridine 
• 186667-92-5 diethyl [1-(3-methylphenyl)pyrrolidin-2-ylidene]malonate 
• 208646-51-9 N-(3-methylphenyl)-6-aminohexan-3-one 
• 186667-87-8 N-(3-methylphenyl)pyrrolidine-2-thione 

Relevant articles and documents

Ruthenium-catalyzed synthesis of: N -substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines

Herein, we report the first example of synthesis of N-substituted lactams via an acceptorless dehydrogenative coupling of diols with primary amines in one step, which was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene-phosphine-phosphine ligand as the catalyst.

Pyrrolidone compound synthesis method

The invention discloses a pyrrolidone compound synthesis method, and belongs to the technical field of organic synthesis. Saturated cyclic tertiary amine 1 is added into solvents, and heating reactionis performed in the presence of oxidizing agent, cupric salt, potassium hydrogen persulfate compound salt (Oxone) and oxygen mixture, additives, elementary iodine or iodated metal salt and the like to obtain pyrrolidone 2. According to the method, a pyrrolidone compound is synthesized by cascade reaction of oxidization retraction, decarbonylation and in-situ oxidization of saturated cyclic tertiary amine compounds, the method has the advantages of simplicity and convenience in operation, mild conditions, wide substrate application range and the like, and an economical, practical, green and environment-friendly novel method is provided for synthesis of the pyrrolidone compound.

Ruthenium-Pincer-Catalyzed Hydrogenation of Lactams to Amino Alcohols

By using the commercially available ruthenium pincer complex (Ru-MACHO-BH) as a catalyst, the challenging direct hydrogenation of lactams and analogues has been successfully accomplished to deliver corresponding value-added amino alcohols in good-to-excellent yields under mild reaction conditions. Remarkably, in addition to N-protected lactams, unprotected ones could also be readily reduced in the presence of a catalytic amount of weak base or even under neutral reaction conditions, which further highlights the broad substrate scope and the protocol efficiency.