24077-98-3

Basic information

• Product Name: 6-Methoxy-2-nitroso-2,3-dihydro-1H-inden-1-one
• Synonyms: 6-Methoxy-2-nitroso-2,3-dihydro-1H-inden-1-one;2-(hydroxyimino)-6-methoxy-2,3-dihydro-1H-inden-1-one
• CAS NO: 24077-98-3
• Molecular Formula: C₁₀H₉NO₃
• Molecular Weight: 191.18336
• Mol File: 24077-98-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 397.1 °C at 760 mmHg
• Flash Point: 193.9 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 5.12E-07mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 6-Methoxy-2-nitroso-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxy-2-nitroso-2,3-dihydro-1H-inden-1-one(24077-98-3)
• EPA Substance Registry System: 6-Methoxy-2-nitroso-2,3-dihydro-1H-inden-1-one(24077-98-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 24077-98-3(Hazardous Substances Data)

Usage

General Description

6-Methoxy-2-nitroso-2,3-dihydro-1H-inden-1-one is a chemical compound with the molecular formula C10H9NO3. It is a derivative of indenone, containing a nitroso group and a methoxy group on the aromatic ring. 6-Methoxy-2-nitroso-2,3-dihydro-1H-inden-1-one is a yellow to brown crystalline solid that is sparingly soluble in water. It is commonly used as a reagent in organic synthesis and has been found to exhibit antitumor and anti-inflammatory properties. Additionally, it has been used in the production of pharmaceuticals and other fine chemicals. Overall, 6-Methoxy-2-nitroso-2,3-dihydro-1H-inden-1-one is an important compound in the field of organic chemistry with various applications.

InChI:InChI=1/C10H9NO3/c1-14-7-3-2-6-4-9(11-13)10(12)8(6)5-7/h2-3,5,13H,4H2,1H3

Upstream product

• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 110-46-3 isopentyl nitrite 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 

Downstream Products

• 82117-25-7 3-chloroisoquinolin-7-ol 
• 82117-21-3 3-chloro-7-methoxyisoquinoline 
• 24623-40-3 1,3-dichloro-7-methoxyisoquinoline 
• 5450-76-0 2-amino-6-methoxy-1-indanone hydrochloride 
• 76254-25-6 2-cyanomethyl-5-methoxy-benzoic acid 
• 73305-09-6 (±)-2-amino-5-methoxyindane 

Relevant articles and documents

Efficient diastereoselective synthesis of cis-2-amino-1-indanol derivatives and cis- and trans-1-amino-2-indanol via Pd-catalyzed hydrogenation

(±)-cis-2-amino-1-indanol was diastereoselectively synthesized from 1,2-indanedion-2-oxime in ethanol at 25 °C under 10% Pd/C-catalyzed hydrogenation conditions. Under the same hydrogenation condition, 1,2-indanedion-2-oxime and their derivatives having one and/or two electron-donating groups in aliphatic or aromatic part of indanyl ring were diastereoselectively reduced to racemic cis-2-amino-1-indanol derivatives. From 1,2-indanedion-1-oxime, (±)-trans-1-amino-2-indanol was obtained in ethanol at 25 °C over a 10% Pd/BaSO4 catalyst. In contrast, the 10% Pd/BaSO4-catalyzed hydrogenation reaction in ethanol at 45 °C afforded cis-1-hydroxyamino-2-indanol from 1,2-indanedion-1-oxime, followed by reduction to form (±)-cis-1-amino-2-indanol. The diastereoselectivity of β-aminoindanols was dependent on the Pd catalyst, reaction temperature, and pH of the reaction medium.

Cu-catalyzed coupling of indanone oxime acetates with thiols to 2,3-difunctionalized indenones

A Cu-catalyzed coupling reaction of indanone oxime acetates with thiols has been developed for the synthesis of 2,3-functionalized 1-indenones. This protocol has several features including easy mild reaction conditions, stabilized enamine products, good t

BICYCLIC ARYL MONOBACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS

The present invention relates to bicyclic aryl monobactam compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A1, L, M, W, X, Y, Z, RX and Rz are as defined herein. The present invention also relates to compositions which comprise a bicyclic aryl monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of one or more beta-lactamase inhibitor compounds.